U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C42H69O11.Na
Molecular Weight 772.9804
Optical Activity UNSPECIFIED
Defined Stereocenters 18 / 18
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SALINOMYCIN SODIUM

SMILES

[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@]2([H])O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@@]5([H])CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)[C@@H](CC)C([O-])=O

InChI

InChIKey=YPZYGIQXBGHDBH-UZHRAPRISA-M
InChI=1S/C42H70O11.Na/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33;/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47);/q;+1/p-1/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C42H69O11
Molecular Weight 749.9907
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 18 / 18
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23517602 | http://www.merck-animal-health-usa.com/binaries/intp1069_SACOX_tcm96-86731.pdf

Salinomycin Sodium is active against certain Gram-positive bacteria, while Gram-negative species are resistant. The use of Salinomycin Sodium as a feed additive at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli, and Campylobacter or to induce resistance and cross-resistance to antimicrobials important in human and animal therapy. Salinomycin Sodium is safe for chickens for fattening at a concentration of 70 mg/kg complete feed with a margin of safety of 1.7. For chickens reared for laying, 50 mg Salinomycin Sodium /kg complete feed is considered safe for a feeding period of the first 12 weeks of life; a margin of safety cannot be given. The simultaneous use of Salinomycin Sodium and certain antibiotic drugs (e.g. tiamulin) is contraindicated. Salinomycin Sodium is absorbed to a certain extent in the chicken and extensively metabolized. Unchanged Salinomycin Sodium represents a very small fraction of the metabolites in tissue and excreta. Many metabolites, predominantly mono- and multi-hydroxylated, have been identified in tissues and excreta. The metabolites in excreta showed a higher degree of hydroxylation than in the liver. Salinomycin -related metabolites have a reduced ionophoric activity when compared with Salinomycin. Salinomycin is considered the MR; ratios of MR to total residue are available for all relevant tissues for 1 and 6 h withdrawal. No residues eggs are expected provided that the proposed maximum dose and duration of administration are respected.

Originator

Sources: JP47025392

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Sacox

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Comparative investigation of salinomycin and flavophospholipol in sheep fed different composed diets.
2001
Effect of antibiotics on in vitro and in vivo avian cartilage degradation.
2002 Jan-Mar
Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells.
2002 Mar-Apr
Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed.
2003 Apr-Jun
Cloning of modular type I polyketide synthase genes from salinomycin producing strain of Streptomyces albus.
2003 Aug 5
Growth enhancement in broiler chickens receiving CHEMEQRTM polymeric antimicrobial.
2003 Dec
LC determination of salinomycin in fermentation broths and premixes.
2003 Feb 26
Beneficial effect of beta-mannanase feed enzyme on performance of chicks challenged with Eimerla sp. and Clostridium perfringens.
2003 Jul-Sep
Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss.
2003 Jun 20
Determination of antibiotics from soil by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.
2003 Jun 27
Pancreatic lipase activity as influenced by unconjugated bile acids and pH, measured in vitro and in vivo.
2003 May
Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP.
2003 Oct 1
A new method for in vitro detection of microbially produced mitochondrial toxins.
2003 Oct-Dec
Ionophores: their use as ruminant growth promotants and impact on food safety.
2003 Sep
Comparison of microwave assisted extraction with conventional (homogenization, vortexing) for the determination of incurred salinomycin in chicken eggs and tissues.
2004
[Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].
2004 Apr
Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin.
2004 Apr
Rapid time-resolved fluoroimmunoassay for the screening of narasin and salinomycin residues in poultry and eggs.
2004 Apr 7
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations.
2004 Apr-Jun
Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo.
2004 Dec 13
Susceptibility of Clostridium perfringens strains from broiler chickens to antibiotics and anticoccidials.
2004 Feb
A field study on the effect of the dietary use of a clinoptilolite-rich tuff, alone or in combination with certain antimicrobials, on the health status and performance of weaned, growing and finishing pigs.
2004 Feb
Isolation and selection of ionophore-tolerant Eimeria precocious lines: E. tenella, E. maxima and E. acervulina.
2004 Feb 6
Evaluation of zinc against salinomycin toxicity in broilers.
2004 Jan
A case of human poisoning by salinomycin, an agricultural antibiotic.
2004 Mar 12
The effects of salinomycin and roxarsone on the performance of broilers when included in the feed for four, five, or six weeks and infected with Eimeria species during the starter or grower phase of production.
2004 May
Coccidiosis control by administering toltrazuril in the drinking water for a 2-day period.
2004 May 7
An unaddressed issue of agricultural terrorism: a case study on feed security.
2004 Nov
Development of multiclass methods for drug residues in eggs: silica SPE cleanup and LC-MS/MS analysis of ionophore and macrolide residues.
2004 Nov 17
Antiparasitic and immunomodulatory effect of innovative treatments against Myxobolus sp. infection in Diplodus puntazzo.
2005 Dec 10
Performance and nutrient retention responses of broilers to dietary oxyhalogenic and ionic salts.
2005 Feb
The impact of a successful anti-myxosporean treatment on the phagocyte functions of juvenile and adult Sparus aurata L.
2005 Jan-Mar
Effects of Natustat supplementation on performance, feed efficiency and intestinal lesion scores in broiler chickens challenged with Eimeria acervulina, Eimeria maxima and Eimeria tenella.
2005 Jun 30
Incidence of residues of nine anticoccidials in eggs.
2005 Nov
HPLC determination of salinomycin and related compounds in fermentation media of Streptomyces albus and premixes.
2005 Sep 15
Tiamulin resistance in porcine Brachyspira pilosicoli isolates.
2006 Feb
Elimination of macrolides, tiamulin, and salinomycin during manure storage.
2006 Jul
Evaluation of a Bacillus stearothermophilus tube test as a screening tool for anticoccidial residues in poultry.
2006 Jun
Simultaneous determination of four coccidiostats in eggs and broiler meat: validation of an LC-MS/MS method.
2006 May
Increased level of Eimeria sensitivity to diclazuril after using a live coccidial vaccine.
2006 Sep
Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium.
2007 Aug 15
Microarchitecture and spatial relationship between bacteria and ileal, cecal, and colonic epithelium in chicks fed a direct-fed microbial, PrimaLac, and salinomycin.
2007 Jun
Impact of salinomycin on the intestinal microflora of broiler chickens.
2007 Oct 26
Pharmacological evaluation of contractile activity of the dog heartworm Dirofilaria immitis.
2008 Mar
Occurrence and elimination of antibiotics at four sewage treatment plants in Japan and their effects on bacterial ammonia oxidation.
2009
Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii.
2009 Apr
Synergistic fungicidal activities of polymyxin B and ionophores, and their dependence on direct disruptive action of polymyxin B on fungal vacuole.
2009 Feb
Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027.
2009 Jan 22
Dietary supplementation of mannan-oligosaccharide enhances neonatal immune responses in chickens during natural exposure to Eimeria spp.
2009 Mar 19
Fast liquid chromatography/multiple-stage mass spectrometry of coccidiostats.
2009 May
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Salinomycin (Sal) could directly reduce the cell viability and induce apoptosis in SGC-7901 cancer cells in vitro. Sal inhibited constitutive STAT3 activation by blocking its DNA binding and reduced various gene products including Bcl-2, Bcl-xL and VEGF both at mRNA and protein levels
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:35:58 GMT 2023
Edited
by admin
on Fri Dec 15 15:35:58 GMT 2023
Record UNII
92UOD3BMEK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SALINOMYCIN SODIUM
GREEN BOOK  
Common Name English
SALINOMYCIN SODIUM SALT [MI]
Common Name English
SALINOMYCIN SODIUM SALT
MI  
Common Name English
SALINOPHARM-PREMIX
Common Name English
SACOX
Common Name English
NSC-751548
Code English
SALINOMYCIN, SODIUM SALT (1:1)
Common Name English
SALINOMYCIN SODIUM [GREEN BOOK]
Common Name English
SODIUM SALINOMYCIN
Common Name English
SALINOMYCIN, MONOSODIUM SALT
Common Name English
Code System Code Type Description
PUBCHEM
23703990
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
CAS
55721-31-8
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
RXCUI
1812261
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
NSC
751548
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
FDA UNII
92UOD3BMEK
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
MERCK INDEX
m9743
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY Merck Index
DAILYMED
92UOD3BMEK
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
DRUG BANK
DBSALT001701
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID1045902
Created by admin on Fri Dec 15 15:35:58 GMT 2023 , Edited by admin on Fri Dec 15 15:35:58 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE