DIPROQUALONE CAMSILATE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C12H14N2O3.C10H16O4S
Molecular Weight	466.548
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)[C@@H]2CC[C@@]1(CS(O)(=O)=O)C(=O)C2.CC3=NC4=CC=CC=C4C(=O)N3CC(O)CO

InChI

InChIKey=AJNMCFBQWSXQHS-STOWLHSFSA-N

InChI=1S/C12H14N2O3.C10H16O4S/c1-8-13-11-5-3-2-4-10(11)12(17)14(8)6-9(16)7-15;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,9,15-16H,6-7H2,1H3;7H,3-6H2,1-2H3,(H,12,13,14)/t;7-,10-/m.1/s1

HIDE SMILES / InChI

Molecular Formula	C12H14N2O3
Molecular Weight	234.2512
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C10H16O4S
Molecular Weight	232.297
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20232372 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 457, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | (2013) Progress in Drug Research, page 272, retrieved from: https://books.google.ru/books?id=wFX2BwAAQBAJ

Diproqualone was used primarily for the treatment of inflammatory pain associated with osteoarthritis. The analgesic activity of diproqualoneis synergistic with that of noramidopyrine. It also display anti-inflammatory action in the rat, inhibiting plantar edema with dextran or serotonin, atopic edema from ovalbumin, etc. It has spasmolytic, anticholinergic and antihistaminic action in higher doses. It is not hypnotic and has no anticonvulsant effects. The therapeutic symptoms for diproqualone are all types of pain: postoperative, posttraumatic, dental, neuritis, anti-inflammatory arthritis, etc.

Approval Year

PubMed

Title	Date	PubMed
Synthesis of new 2,3-dihydroquinazolin-4(1H)-one derivatives for analgesic and anti-inflammatory evaluation.	2010 May	20232372

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:55:32 GMT 2023` Edited by `admin` on `Sat Dec 16 07:55:32 GMT 2023`
Record UNII	92QYQ513QO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIPROQUALONE CAMSILATE

Common Name

English

4(3H)-QUINAZOLINONE, 3-(2,3-DIHYDROXYPROPYL)-2-METHYL-, MONO((1S)-7,7-DIMETHYL-2-OXOBICYCLO(2.2.1)HEPTANE-1-METHANESULFONATE) (SALT)

Common Name

English

BICYCLO(2.2.1)HEPTANE-1-METHANESULFONIC ACID, 7,7-DIMETHYL-2-OXO-, (1S)-, COMPD. WITH 3-(2,3-DIHYDROXYPROPYL)-2-METHYL-4(3H)-QUINAZOLINONE (1:1)

Systematic Name

English

Diproqualone camsilate [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

92QYQ513QO