KETAZOLAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H17ClN2O3
Molecular Weight	368.814
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of KETAZOLAM

Structure Search

SMILES

CN1C2=C(C=C(Cl)C=C2)C3(OC(C)=CC(=O)N3CC1=O)C4=CC=CC=C4

InChI

InChIKey=PWAJCNITSBZRBL-UHFFFAOYSA-N

InChI=1S/C20H17ClN2O3/c1-13-10-18(24)23-12-19(25)22(2)17-9-8-15(21)11-16(17)20(23,26-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C20H17ClN2O3
Molecular Weight	368.814
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6108335 | https://www.ncbi.nlm.nih.gov/pubmed/11443263 | http://www.hmdb.ca/metabolites/HMDB0015526

KETAZOLAM, a benzodiazepine with an additional d-face-fused heterocyclic ring, possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used for the treatment of anxiety and spasticity.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Double-blind placebo-controlled efficacy study of ketazolam (U-28,774).	1976	16791
Anxiolytic efficacy and safety of ketazolam compared with diazepam and placebo.	1980	6105920
Ketazolam and diazepam in anxiety: a controlled study.	1980 Oct	6108335
Ketazolam.	2001 Jul	11443263

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:35 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:35 GMT 2023`
Record UNII	92A214MD7Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KETAZOLAM

Official Name

English

KETAZOLAM [USAN]

Common Name

English

UNAKALM

Brand Name

English

U-28,774

Code

English

U-28774

Code

English

ANSIETEN

Brand Name

English

ANXON

Brand Name

English

(±)-KETAZOLAM

Common Name

English

11-CHLORO-8,12B-DIHYDRO-2,8-DIMETHYL-12B-PHENYL-4H-(1,3)OXAZINO(3,2-D)(1,4)BENZODIAZEPINE-4,7(6H)-DIONE

Common Name

English

ANSEREN

Brand Name

English

Ketazolam [WHO-DD]

Common Name

English

4H-(1,3)OXAZINO(3,2-D)(1,4)BENZODIAZEPINE-4,7(6H)-DIONE, 11-CHLORO-8,12B-DIHYDRO-2,8-DIMETHYL-12B-PHENYL-

Systematic Name

English

ketazolam [INN]

Common Name

English

KETAZOLAM [MI]

Common Name

English

KETAZOLAM [MART.]

Common Name

English

NSC-338158

Code

English

CONTAMEX

Brand Name

English

LOFTRAN

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QN05BA10

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

WHO-ATC

N05BA10

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

NCI_THESAURUS

C1012

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

DEA NO.

2772

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

Code System Code Type Description

WIKIPEDIA

KETAZOLAM

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

PRIMARY

MESH

C002072

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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PUBCHEM

33746

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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CAS

103794-94-1

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

SUPERSEDED

DRUG CENTRAL

1525

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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EPA CompTox

DTXSID20865350

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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ECHA (EC/EINECS)

248-346-3

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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FDA UNII

92A214MD7Y

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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MERCK INDEX

m6615

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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Merck Index

NSC

338158

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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RXCUI

28181

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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RxNorm

SMS_ID

100000082849

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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CAS

27223-35-4

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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EVMPD

SUB08368MIG

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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DRUG BANK

DB01587

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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ChEMBL

CHEMBL2104356

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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NCI_THESAURUS

C83854

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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INN

3107

Created by admin on Fri Dec 15 15:20:35 GMT 2023 , Edited by admin on Fri Dec 15 15:20:35 GMT 2023

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Related Record Type Details


					92A214MD7Y

KETAZOLAM

ACTIVE MOIETY