PHTHALAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2
Molecular Weight	130.1466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CC=C2C=NN=CC2=C1

InChI

InChIKey=LFSXCDWNBUNEEM-UHFFFAOYSA-N

InChI=1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H

HIDE SMILES / InChI

Molecular Formula	C8H6N2
Molecular Weight	130.1466
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Design and synthesis of selective and potent orally active S1P5 agonists.	2010-10-04	20815011
Augmentation of the antileukemia potency of total-body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK).	2010-10	20731589
Associative and dissociative mechanisms in the formation of phthalazine bridged organodiplatinum(II) complexes.	2010-09-20	20712374
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.	2010-09-09	20684549
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.	2010-08-01	20594845
Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives.	2010-08	20537434
2-[1-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)-1H-benzimidazol-2-yl]benzoic acid methanol solvate.	2010-07-17	21588343
Development of improved models for phosphodiesterase-4 inhibitors with a multi-conformational structure-based QSAR method.	2009-12-31	20161837
4-Hydr-oxy-6-[(4-hydr-oxy-1-oxo-1,2-dihydro-phthalazin-6-yl)carbon-yl]phthalazin-1(2H)-one.	2009-11-11	21578782
Phthalocyanine-C60 fused conjugates exhibiting molecular orbital interactions depending on the solvent polarity.	2009-11-02	19866461
Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine.	2009-11	19570595
3-Methyl-1,2,4-triazolo[3,4-a]phthalazine monohydrate.	2009-10-10	21578298
Novel phthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme.	2009-09	19534678
Evaluation of solvent effects on protonation using NMR spectroscopy: implication in salt formation.	2009-07-30	19463928
Dichloridobis(phenanthridine-κN)zinc(II).	2009-06-06	21582680
Theoretical quest for photoconversion molecules having opposite directions of the electric dipole moment in S0 and S1 states.	2009-05-14	19449925
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phthalazin-1(2H)-one.	2009-04-08	21584014
S(N)(H) approach in the synthesis of nitronyl nitroxides.	2009-04-03	19253969
Ultrasound assisted reactions of steroid analogous of anticipated biological activities.	2009-03	19081283
Practical synthesis of a p38 MAP kinase inhibitor.	2009-01-16	19086898
Microwave assisted reactions of some azaheterocylic compounds.	2009-01-15	19145217
Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1.	2009	19401776
A new structure-based QSAR method affords both descriptive and predictive models for phosphodiesterase-4 inhibitors.	2008-11-06	20161841
Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.	2008-10-23	18817365
Structural basis for ligand recognition at the benzodiazepine binding site of GABAA alpha 3 receptor, and pharmacophore-based virtual screening approach.	2008-10	18565775
Synthesis of 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non-7-enes by cyclization of 1,3-bis(silyl enol ethers) with quinazolines.	2008-08-21	18688489
Multiple surface plasmon resonances and near-infrared field enhancement of gold nanowells.	2008-07-01	18507399
A new class of luminescent tricarbonyl rhenium(I) complexes containing bridging 1,2-diazine ligands: electrochemical, photophysical, and computational characterization.	2008-05-19	18422309
Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity.	2008-05-01	18420406
N,N'-Bis(4-chloro-phen-yl)urea.	2008-04-26	21202403
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.	2008-04-15	18321715
Role of phosphodiesterase 5 in synaptic plasticity and memory.	2008-04	18728748
2-(2-Hydroxy-ethyl)phthalazin-1(2H)-one.	2008-03-29	21202145
(1R,2R)-4-Benzoyl-2-benzo-yloxy-1-phenyl-butyl imidazole-1-carboxyl-ate.	2008-02-22	21201953
(2S,4'R,5'R)-(E)-tert-Butyl 2-acetyl-2-(2-oxo-5-phenyl-1,3-dioxolan-4-ylmeth-yl)-5-phenyl-pent-4-enoate.	2008-01-30	21201549
Phthalazin-1(2H)-one-picric acid (1/1).	2007-12-06	21200682
Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands.	2007-10-15	17850140
Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace.	2007-04-11	17280812
[Synthesis and characterization of silver-intermediates in the development process of photothermographic material].	2007-04	17608190
1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.	2007-03-01	17222558
Luminescent hydrido-carbonyl clusters of rhenium containing bridging 1,2-diazine ligands.	2006-12-25	17173450
4-(Azolylphenyl)-phthalazin-1-amines: Novel inhibitors of VEGF receptors I and II.	2006-12	17177892
1-(Azolyl)-4-(aryl)-phthalazines: novel potent inhibitors of VEGF receptors I and II.	2006-11	17177884
A dinucleating ligand related to the beta-diketiminates.	2006-08-28	16896444
Evaluation of apoptosis-induction by newly synthesized phthalazine derivatives in breast cancer cell lines.	2006-07-15	16839218
Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives.	2006-01-06	16388628
Oxidative addition of methyl iodide to a new type of binuclear platinum(II) complex: a kinetic study.	2005-11-14	16271001
Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase.	2005-11-01	16143524
VEGF receptor kinase inhibitors: phthalazines, anthranilamides and related structures.	2005-06	20141503
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005-06	15962942

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 19:42:22 GMT 2025` Edited by `admin` on `Wed Apr 02 19:42:22 GMT 2025`
Record UNII	91Y28DM24N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-62484

Preferred Name

English

PHTHALAZINE

Systematic Name

English

PHTHALAZINE [USP IMPURITY]

Common Name

English

PHTHALAZINE [USP-RS]

Common Name

English

PHTHALAZINE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

91Y28DM24N