PHTHALAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2
Molecular Weight	130.1466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CC2=CN=NC=C2C=C1

InChI

InChIKey=LFSXCDWNBUNEEM-UHFFFAOYSA-N

InChI=1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H

HIDE SMILES / InChI

Molecular Formula	C8H6N2
Molecular Weight	130.1466
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites.	2001 Feb 26	11259020
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.	2001 Jan 8	11140727
Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase.	2001 Sep	11558587
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.	2002 Jan 7	11738561
Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand.	2003 Dec 29	14686842
Synthesis and structural characterization of 1-(D-glycosyloxy)phthalazines.	2003 Oct 31	14572713
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.	2004	15625566
Realization of unusual ligand binding motifs in metalated container molecules: synthesis, structures, and magnetic properties of the complexes [(LMe)Ni2(mu-L')]n+ with L'=NO3-, NO2-, N3-, N2H4, pyridazine, phthalazine, pyrazolate, and benzoate.	2004 Apr 2	15054759
Synthesis of 5-azaindolizine derivatives by the palladium-catalyzed intermolecular formal [3+2] cycloaddition of alkylidenecyclopropanes with 1,2-diazines.	2004 Apr 30	15104465
Potent inhibition of human liver aldehyde oxidase by raloxifene.	2004 Jan	14709625
Human liver aldehyde oxidase: inhibition by 239 drugs.	2004 Jan	14681337
Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives.	2004 Jul 1	15186853
Synthesis and characterization of Cu(2)(I,I), Cu(2)(I,II), and Cu(2)(II,II) compounds supported by two phthalazine-based ligands: influence of a hydrophobic pocket.	2004 Mar 8	14989668
Enzymatic catalysis of urea decomposition: elimination or hydrolysis?	2004 Sep 29	15382918
A novel three-component reaction designed by the combinatorial method: heteroarenes, isothiocyanates and isocyanides.	2005	15789568
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.	2005 Feb 10	15689158
Synthesis and luminescence properties of lanthanide complexes incorporating a hydralazine-derived chromophore.	2005 Jan 7	15605158
Phthalazine PDE IV inhibitors: conformational study of some 6-methoxy-1,4-disubstituted derivatives.	2005 Jul 15	15927474
VEGF receptor kinase inhibitors: phthalazines, anthranilamides and related structures.	2005 Jun	20141503
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase.	2005 Nov 1	16143524
Oxidative addition of methyl iodide to a new type of binuclear platinum(II) complex: a kinetic study.	2005 Nov 14	16271001
Evaluation of apoptosis-induction by newly synthesized phthalazine derivatives in breast cancer cell lines.	2006 Apr-Jun	16839218
A dinucleating ligand related to the beta-diketiminates.	2006 Aug 28	16896444
4-(Azolylphenyl)-phthalazin-1-amines: Novel inhibitors of VEGF receptors I and II.	2006 Dec	17177892
Luminescent hydrido-carbonyl clusters of rhenium containing bridging 1,2-diazine ligands.	2006 Dec 25	17173450
Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives.	2006 Jan 6	16388628
1-(Azolyl)-4-(aryl)-phthalazines: novel potent inhibitors of VEGF receptors I and II.	2006 Nov	17177884
[Synthesis and characterization of silver-intermediates in the development process of photothermographic material].	2007 Apr	17608190
Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace.	2007 Apr 11	17280812
Phthalazin-1(2H)-one-picric acid (1/1).	2007 Dec 6	21200682
1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.	2007 Mar 1	17222558
Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands.	2007 Oct 15	17850140
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.	2008 Apr 15	18321715
(1R,2R)-4-Benzoyl-2-benzo-yloxy-1-phenyl-butyl imidazole-1-carboxyl-ate.	2008 Feb 22	21201953
Multiple surface plasmon resonances and near-infrared field enhancement of gold nanowells.	2008 Jul 1	18507399
2-(2-Hydroxy-ethyl)phthalazin-1(2H)-one.	2008 Mar 29	21202145
A new structure-based QSAR method affords both descriptive and predictive models for phosphodiesterase-4 inhibitors.	2008 Nov 6	20161841
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phthalazin-1(2H)-one.	2009 Apr 8	21584014
Development of improved models for phosphodiesterase-4 inhibitors with a multi-conformational structure-based QSAR method.	2009 Dec 31	20161837
Microwave assisted reactions of some azaheterocylic compounds.	2009 Jan 15	19145217
Practical synthesis of a p38 MAP kinase inhibitor.	2009 Jan 16	19086898
Dichloridobis(phenanthridine-κN)zinc(II).	2009 Jun 6	21582680
Ultrasound assisted reactions of steroid analogous of anticipated biological activities.	2009 Mar	19081283
Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine.	2009 Nov	19570595
Phthalocyanine-C60 fused conjugates exhibiting molecular orbital interactions depending on the solvent polarity.	2009 Nov 2	19866461
Novel phthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme.	2009 Sep	19534678
Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives.	2010 Aug	20537434
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.	2010 Aug 1	20594845
2-[1-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)-1H-benzimidazol-2-yl]benzoic acid methanol solvate.	2010 Jul 17	21588343

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:14:11 GMT 2023` Edited by `admin` on `Sat Dec 16 02:14:11 GMT 2023`
Record UNII	91Y28DM24N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHTHALAZINE

Systematic Name

English

NSC-62484

Code

English

PHTHALAZINE [USP IMPURITY]

Common Name

English

PHTHALAZINE [USP-RS]

Common Name

English

PHTHALAZINE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

91Y28DM24N