U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C22H28N2O2.2ClH
Molecular Weight 425.392
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANILERIDINE HYDROCHLORIDE

SMILES

Cl.Cl.CCOC(=O)C1(CCN(CCC2=CC=C(N)C=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=ZYTHLJLPPSSDIP-UHFFFAOYSA-N
InChI=1S/C22H28N2O2.2ClH/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18;;/h3-11H,2,12-17,23H2,1H3;2*1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C22H28N2O2
Molecular Weight 352.4699
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Aniledrine is a narcotic pain reliver. The drug was prescribed as an analgesic in anaesthesia (Leritine brand name), however, it is no longer available on the market. Although the exact mechanism is not fully understood, aniledrine appears to elicit its action by binding to endorphine receptors in CNS.

CNS Activity

Originator

Merck
238
Curator's Comment: # Merck

Approval Year

1957
118
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
LERITINE

Approved Use

Unknown
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
5%
OTHER
https://go.drugbank.com/drugs/DB00913
ANILERIDINE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
450 mg multiple, oral
Studied dose
Dose: 450 mg
Route: oral
Route: multiple
Dose: 450 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/7541439
unhealthy, 41
Health Status: unhealthy
Age Group: 41
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/7541439
Disc. AE: Delirium...
AEs leading to
discontinuation/dose reduction:
Delirium
Sources:
https://pubmed.ncbi.nlm.nih.gov/7541439
AEs

AEs

AESignificanceDosePopulation
Delirium Disc. AE
450 mg multiple, oral
Studied dose
Dose: 450 mg
Route: oral
Route: multiple
Dose: 450 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/7541439
unhealthy, 41
Health Status: unhealthy
Age Group: 41
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/7541439
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:61203
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:61203
ZINC
ZINC000000608179
http://zinc15.docking.org/substances/ZINC000000608179
PubMed

PubMed

TitleDatePubMed
Synthesis, characterization and antimicrobial properties of a Co(II)-phthalylsulfathiazolate complex.
2010-12
Metabolic fate of orally administered phyllodulcin in rats.
2004-09
Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics.
2002-08
Anileridine-induced delirium.
1995-05
Qualitative differences in effects of opioids in man: preliminary evidence for multiple mechanisms of analgesic action.
1986-05
Contact dermatitis to anileridine.
1980-12
Patents

Patents

JP2007507532A
35

Sample Use Guides

In Vivo Use Guide
Aniledrine is administred either orally (in form of hydrochloride salt)
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:45:22 GMT 2025
Edited
by admin
on Mon Mar 31 17:45:22 GMT 2025
Record UNII
915Q054DLC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANILERIDINE HYDROCHLORIDE
MART.   ORANGE BOOK   USP   WHO-DD  
Common Name English
ANILERIDINE DIHYDROCHLORIDE
MI  
Preferred Name English
ISONIPECOTIC ACID, 1-(P-AMINOPHENETHYL)-4-PHENYL-, ETHYL ESTER, DIHYDROCHLORIDE
Common Name English
APODOL
Common Name English
ANILERIDINE HCL
Common Name English
ANILERIDINE DIHYDROCHLORIDE [MI]
Common Name English
ANILERIDINE HYDROCHLORIDE [MART.]
Common Name English
LERITINE DIHYDROCHLORIDE
Common Name English
4-PIPERIDINECARBOXYLIC ACID, 1-(2-(4-AMINOPHENYL)ETHYL)-4-PHENYL-, ETHYL ESTER, DIHYDROCHLORIDE
Common Name English
ETHYL 1-(P-AMINOPHENETHYL)-4-PHENYLISONIPECOTATE DIHYDROCHLORIDE
Common Name English
Anileridine hydrochloride [WHO-DD]
Common Name English
ANILERIDINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
ANILERIDINE HYDROCHLORIDE CII
USP-RS  
Common Name English
ALDINE
Common Name English
LERITINE
Brand Name English
ANILERIDINE HYDROCHLORIDE [USP IMPURITY]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1506
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
NCI_THESAURUS C241
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
Code System Code Type Description
FDA UNII
915Q054DLC
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
ECHA (EC/EINECS)
204-770-0
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
ChEMBL
CHEMBL1201347
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
MESH
C100232
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
PUBCHEM
31338
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
EVMPD
SUB36186
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
WIKIPEDIA
Anileridine hydrochloride
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
RXCUI
235413
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY RxNorm
SMS_ID
100000128735
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
NCI_THESAURUS
C65235
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
CHEBI
61208
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
EPA CompTox
DTXSID50155034
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
EVMPD
SUB00532MIG
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
DRUG BANK
DBSALT001408
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
MERCK INDEX
m1921
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY Merck Index
CAS
126-12-5
Created by admin on Mon Mar 31 17:45:22 GMT 2025 , Edited by admin on Mon Mar 31 17:45:22 GMT 2025
PRIMARY
Related Record Type Details
Structure of ANILERIDINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ANILERIDINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966