FLUOCORTOLONE CAPROATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H39FO5
Molecular Weight	474.6047
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCC(=O)OCC(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

InChIKey=WHZRCUIISKRTJL-YTZKRAOUSA-N

InChI=1S/C28H39FO5/c1-5-6-7-8-24(33)34-15-23(32)25-16(2)11-19-18-13-21(29)20-12-17(30)9-10-27(20,3)26(18)22(31)14-28(19,25)4/h9-10,12,16,18-19,21-22,25-26,31H,5-8,11,13-15H2,1-4H3/t16-,18+,19+,21+,22+,25-,26-,27+,28+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H39FO5
Molecular Weight	474.6047
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700 | https://www.ncbi.nlm.nih.gov/pubmed/3743619
Curator's Comment: description was created based on several sources, including http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1

Fluocortolone is a topical corticosteroid (class of steroid hormones formed in the adrenal gland). Is primary indicated in condition like, Ana fissure, Dermatosis haemorrhoids, proctitis. The signs and symptoms that are produced after the acute overdosage include convulsions, respiratory arrest, allergic skin reactions. Glucocorticoids, such as fluocortolone, act through nuclear hormone receptors Schaaf and Cidlowski (2002). The two members of this family are glucocorticoid receptor (GR) type I and GR type I I. Activation of these sites alters gene expression of endogenous agents that influence immune and inflammatory responses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 173 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700	Binding Agent 1076

Conditions

Condition	Modality	Highest Phase	Product
Anal fissure 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Haemorrhoids 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Proctitis 4 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Operational post-keratopasty graft tolerance due to differential HLAMatchmaker matching.	2010-11-11	21152438
Update on the management of chronic eczema: new approaches and emerging treatment options.	2010-07-28	21437065
Prevention and treatment of intertrigo in large skin folds of adults: a systematic review.	2010-07-13	20626853
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010-04	20155493
A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy.	2010-01	19865824
Mycophenolate mofetil (MMF) following penetrating high-risk keratoplasty: long-term results of a prospective, randomised, multicentre study.	2009-11	19151659
[Retinochoroidopathy after intravitreal anti-VEGF treatment].	2009-08	18953546
Adalimumab for the treatment of fistulas in patients with Crohn's disease.	2009-07	19201775
A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples.	2009-04	20336223
Stenotrophomonas maltophilia induced post-cataract-surgery endophthalmitis: Outbreak investigation and clinical courses of 26 patients.	2009-04	19148575
Transrepression and transactivation potencies of inhaled glucocorticoids.	2008-12	19177906
Adherence to clocortolone pivalate cream 0.1% in a pediatric population with atopic dermatitis.	2008-05	18543596
Varicella chorioretinitis.	2007-12	18028120
German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version).	2007-06	17497162
[Sudden hearing loss in a patient with a 3-mm acoustic tumor].	2007	17527067
Oral and intralesional steroid therapy in giant cell granuloma.	2006-06	16720455
An open prospective pilot study on the use of rapamycin after penetrating high-risk keratoplasty.	2006-03-15	16534481
Recurrent optic disc and retinal vasculitis in a patient with drug-induced urticarial vasculitis.	2006	17162415
[Ranking of systemic steroids after normal-risk keratoplasty. Results of a randomized prospective study].	2005-05	15657693
Immunosuppression with cyclosporine A and mycophenolate mofetil after penetrating high-risk keratoplasty: a retrospective study.	2005-04-27	15849551
Topical FK506 as immunoprophylaxis after allogeneic penetrating normal-risk keratoplasty: a randomized clinical pilot study.	2005-02	15691272
Clinical results of anti-inflammatory therapy in Graves' ophthalmopathy and association with thyroidal autoantibodies.	2004-11	15521965
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy.	2004-07	15220743
Childhood lichen planus with nail involvement: a case.	2003-12-31	14696806
[Bilateral uveitis intermedia. A 15-year clinical course].	2003-12	14704828
Orbital myositis in a patient with primary biliary cirrhosis: successful treatment with methotrexate and corticosteroids.	2003-11	14650113
Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis.	2003-08	12953943
An integrative approach to eczema (atopic dermatitis).	2003-02-25	12597676
A case of cutaneous delayed-type allergy to oral dexamethasone and to betamethasone.	2002	12037457
Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial.	2001-06	11482341
Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial.	2001-04	11297592
Contact allergies to topical corticosteroids: 10 cases of contact dermatitis.	1991-08	1834432

Patents

Sample Use Guides

In Vivo Use Guide

adult: 0.025 %; Frequency: 8 hours

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:10:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:10:41 GMT 2025`
Record UNII	90893P8662
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUOCORTOLONE 21-HEXANOATE

Preferred Name

English

FLUOCORTOLONE CAPROATE

Official Name

English

6.ALPHA.-FLUORO-11.BETA.-HYDROXY-21-HEXANOYLOXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

FLUOCORTOLONE CAPROATE [USAN]

Common Name

English

FLUOCORTOLONE 21-HEXANOATE [MI]

Common Name

English

SH-770

Code

English

Fluocortolone caproate [WHO-DD]

Common Name

English

FICOID

Brand Name

English

FLUOCORTOLONE 21-CAPROATE

Common Name

English

ULTRALANUM

Brand Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11-HYDROXY-16-METHYL-21-((1-OXOHEXYL)OXY)-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

FLUOCORTOLONE CAPROATE [MART.]

Common Name

English

6?-Fluoro-11?,21-dihydroxy-16?-methylpregna-1,4-diene-3,20-dione 21-hexanoate

Systematic Name

English

SH 770

Code

English

FLUOCORTOLONE HEXANOATE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6.ALPHA.-FLUORO-11.BETA.,21-DIHYDROXY-16.ALPHA.-METHYL-, 21-HEXANOATE

Systematic Name

English

HEXANOIC ACID, 21-ESTER WITH 6.ALPHA.-FLUORO-11.BETA.,21-DIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2107415