Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | F.K |
| Molecular Weight | 58.0967 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[F-].[K+]
InChI
InChIKey=NROKBHXJSPEDAR-UHFFFAOYSA-M
InChI=1S/FH.K/h1H;/q;+1/p-1
| Molecular Formula | FH |
| Molecular Weight | 20.0063 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | K |
| Molecular Weight | 39.0983 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588
Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2331043 |
|||
Target ID: CHEMBL2095186 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | POTASSIUM HYDROXIDE Approved UseUsed as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office. Launch Date2010 |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Kayexalate Approved UseINDICATION AND USAGE
Kayexalate is indicated for the treatment of hyperkalemia. Launch Date1958 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency. | 1972 |
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| Delayed cystitis due to cyclophosphamide. | 1979 Jan 4 |
|
| A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k. | 1993 Mar 30 |
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| Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. | 1994 Dec 20 |
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| Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. | 1994 Dec 20 |
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| Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. | 1997 Aug 15 |
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| Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts. | 1997 Feb |
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| Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. | 1997 Nov |
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| Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. | 1998 Mar 6 |
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| Molecular characterization of a broad selectivity neutral solute channel. | 1998 Sep 18 |
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| Role of aquaporin water channels in pleural fluid dynamics. | 2000 Dec |
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| Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. | 2000 Oct |
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| Cloning and functional expression of an MIP (AQP0) homolog from killifish (Fundulus heteroclitus) lens. | 2001 Dec |
|
| Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. | 2001 Jan 5 |
|
| Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study. | 2002 Aug 1 |
|
| Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. | 2002 Feb 15 |
|
| NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK. | 2003 Mar |
|
| Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. | 2003 May |
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| [Water permeability of the OMCD and IMCD cells' basolateral membrane under the conditions of dehydration and dDAVP action]. | 2004 Jul |
|
| Biochemistry. Water photolysis in biology. | 2004 Mar 19 |
|
| Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney. | 2004 Oct |
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| Reversible silencing of CFTR chloride channels by glutathionylation. | 2005 Feb |
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| Effect of dioxane on the structure and hydration-dehydration of alpha-chymotrypsin as measured by FTIR spectroscopy. | 2005 Jun 15 |
|
| The mineralocorticoid receptor: a journey exploring its diversity and specificity of action. | 2005 Sep |
|
| Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. | 2006 Feb 21 |
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| The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. | 2006 Jan |
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| The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first? | 2006 Oct 30 |
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| Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. | 2007 Dec |
|
| Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). | 2007 Jun 19 |
|
| Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. | 2007 May |
|
| A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. | 2009 Feb |
|
| Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis. | 2009 Jul |
|
| Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata). | 2009 Nov |
|
| Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla). | 2009 Sep 1 |
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| Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. | 2010 Apr 21 |
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| Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. | 2010 Aug 1 |
|
| Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. | 2010 Sep 6 |
|
| Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. | 2011 Apr |
|
| Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken. | 2011 Jan |
|
| Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes. | 2011 Mar |
|
| Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. | 2011 Mar |
|
| Water permeability and characterization of aquaporin-11. | 2011 May |
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| Inhibition of aquaporin-3 water channel in the colon induces diarrhea. | 2012 |
|
| Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation. | 2012 Apr |
|
| Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation. | 2012 Feb 1 |
|
| Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells. | 2012 Jun |
|
| Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. | 2012 Jun 1 |
|
| A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel. | 2012 May |
|
| Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD). | 2012 Sep |
|
| Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. | 2013 Feb |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:53:16 GMT 2023
by
admin
on
Fri Dec 15 16:53:16 GMT 2023
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| Record UNII |
9082WG1G3F
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| Record Status |
Validated (UNII)
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| Record Version |
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232-151-5
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C033320
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POTASSIUM FLUORIDE
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SUB14977MIG
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DTXSID8031940
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9082WG1G3F
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522689
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100000079194
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7789-23-3
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66872
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m9023
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7481
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE | |||
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SOLVATE->ANHYDROUS |
