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Details

Stereochemistry ACHIRAL
Molecular Formula C7H8ClN3O4S2.ClH
Molecular Weight 334.2024
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCHLOROTHIAZIDE HYDROCHLORIDE

SMILES

c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)N)Cl.Cl

InChI

InChIKey=HNLAFWZKHCUIMC-UHFFFAOYSA-N
InChI=1S/C7H8ClN3O4S2.ClH/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-2,10-11H,3H2,(H2,9,12,13);1H

HIDE SMILES / InChI

Molecular Formula C7H8ClN3O4S2
Molecular Weight 297.7415
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: Description was created based on several sources, including: https://www.drugs.com/cdi/capozide.html http://www.rxlist.com/capozide-drug.htm

CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) for oral administration combines two antihypertensive agents: captopril and hydrochlorothiazide. The mechanism of action of captopril has not yet been fully elucidated. Captopril prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE, a peptidyldipeptide carboxy hydrolase. Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na+) reabsorption in the distal convoluted tubule. CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) is indicated for the treatment of hypertension. The blood pressure lowering effects of captopril and thiazides are approximately additive. Major side effects are: Black, tarry stools; chest pain; chills; cough; fever; painful or difficult urination; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; unusual bleeding or bruising; unusual tiredness or weakness. It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension. Captopril’s effect will be augmented by antihypertensive agents that cause renin release. For example, diuretics (e.g., thiazides) may activate the renin-angiotensin-aldosterone system.

CNS Activity

Originator

Curator's Comment:: Captopril: E. R. Squibb & Sons, Inc. https://www.google.com/patents/US4046889 https://www.google.com/patents/US4105776 Hydrochlorothiazide: G. de StevensL. H. WernerA. HalamandarisS. RiccaJr. https://www.ncbi.nlm.nih.gov/pubmed/13619659

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CAPOZIDE

Approved Use

CAPOZIDE® (captopril and hydrochlorothiazide tablets, USP) is indicated for the treatment of hypertension. The blood pressure lowering effects of captopril and thiazides are approximately additive.

Launch Date

4.66300797E11
PubMed

PubMed

TitleDatePubMed
Captopril and hydrochlorothiazide combined: Acezide/Capozide.
1989 Jul 24
Captopril versus captopril plus hydrochlorothiazide for essential hypertension in Koreans.
1991 Jan 1
Captopril and hydrochlorothiazide (Capozide) combine to enhance the reduction in voluntary alcohol intake in rats.
1993 Oct
[Capozide-50 alone and in combination with melatonin in therapy of hypertension].
2000
Patents

Sample Use Guides

therapy may be instituted with a single tablet of CAPOZIDE (captopril/hydrochlorothiazide) 25 mg/15 mg taken once daily. For patients insufficiently responsive to the initial dose, additional captopril or hydrochlorothiazide may be added as individual components or by using CAPOZIDE (captopril/hydrochlorothiazide) 50 mg/15 mg, 25 mg/25 mg or 50 mg/25 mg, or divided doses may be used. Daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: The present study shows that 1-100 microM hydrochlorothiazide (HCTZ) dose dependently inhibits bone resorption by isolated rat osteoclasts in the bone slice assay with an IC50 of approximately 20 microM. https://www.ncbi.nlm.nih.gov/pubmed/7820777
In the presence of captopril (2 X 10^4 M), contractile responses to angiotensln I (5 X 10^10 to 5 X 10^8 M) were attenuated significantly.
Substance Class Chemical
Created
by admin
on Sat Jun 26 11:48:17 UTC 2021
Edited
by admin
on Sat Jun 26 11:48:17 UTC 2021
Record UNII
8ZJA0NWF31
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROCHLOROTHIAZIDE HYDROCHLORIDE
Common Name English
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3,4-DIHYDRO-, 1,1-DIOXIDE, HYDROCHLORIDE
Systematic Name English
HYDROCHLOROTHIAZIDE HCL
Common Name English
Code System Code Type Description
PUBCHEM
148451
Created by admin on Sat Jun 26 11:48:18 UTC 2021 , Edited by admin on Sat Jun 26 11:48:18 UTC 2021
PRIMARY
CAS
42461-28-9
Created by admin on Sat Jun 26 11:48:18 UTC 2021 , Edited by admin on Sat Jun 26 11:48:18 UTC 2021
NON-SPECIFIC STOICHIOMETRY
EPA CompTox
42461-28-9
Created by admin on Sat Jun 26 11:48:18 UTC 2021 , Edited by admin on Sat Jun 26 11:48:18 UTC 2021
PRIMARY
FDA UNII
8ZJA0NWF31
Created by admin on Sat Jun 26 11:48:18 UTC 2021 , Edited by admin on Sat Jun 26 11:48:18 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY