Besufetamig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:01:50 GMT 2025` Edited by `admin` on `Wed Apr 02 12:01:50 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8YCQ8727FB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ONO-4685

Preferred Name

English

Besufetamig

Official Name

English

besufetamig [INN]

Common Name

English

H-gamma1 heavy chain anti-PDCD1 Homo sapiens (1-456) [VH (Homo sapiens IGHV7-4-1*02 (90.8%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (122), CDR-IMGT [8.8.20] (26-33.51-58.97-116)) (1-127) -Homo sapiens IGHG1*03 G1m3, nG1m1 CH1 R120, CH3 E12, M14, 6-G1v59-1 CH2 G

Common Name

English

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-kappa), anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens monoclonal antibody, bispecific;

Common Name

English

Immunoglobulin G1 [de-C-terminal lysine], bispecific, anti-(human programmed cell death protein 1) (human monoclonal ONO-4685 ?1-chain), (236?227?),(239?230?)-bis(disulfide) with immunoglobulin G1 [de-C-terminal lysine] anti-(human CD3 antigen) (human mo

Common Name

English

Code System Code Type Description

FDA UNII

8YCQ8727FB

Created by admin on Wed Apr 02 12:01:50 GMT 2025 , Edited by admin on Wed Apr 02 12:01:50 GMT 2025

PRIMARY

CAS

3037124-22-1

Created by admin on Wed Apr 02 12:01:50 GMT 2025 , Edited by admin on Wed Apr 02 12:01:50 GMT 2025

PRIMARY

INN

13363

Created by admin on Wed Apr 02 12:01:50 GMT 2025 , Edited by admin on Wed Apr 02 12:01:50 GMT 2025

PRIMARY

From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_368	2_426
2_262	2_322
2_221	4_214
2_145	2_201
2_22	2_96
1_377	1_435
1_271	1_331
1_239	2_230
1_236	2_227
1_230	3_214
1_154	1_210
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_307
N	2_298

Related Record Type Details


					8YCQ8727FB

Besufetamig

ACTIVE MOIETY

Comments:

ONO-4685 binds specifically to human PD-1 and human CD3 and induces cytotoxic activity of human T cells against PD-1-expressing target cells.

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL