Amdokitug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 21:17:18 GMT 2025` Edited by `admin` on `Wed Apr 02 21:17:18 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	8X769U9BGL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain (1-445) [VH (Homo sapiens IGHV3-23*04 (89.8%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.7.9] (26-33.51-57.96-104)) (1-115) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K(212) (116-213), hinge 1-15 (21

Preferred Name

English

Amdokitug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (Interleukin 17A, IL-17)], monoclonal antibody

Common Name

English

Immunoglobulin G1, anti-(human interleukin 17A) (human-Mus musculus monoclonal 608 ?1-chain), disulfide with human-Mus musculus monoclonal 608 ?-chain, dimer

Common Name

English

amdokitug [INN]

Common Name

English

Code System Code Type Description

CAS

3012586-05-6

Created by admin on Wed Apr 02 21:17:18 GMT 2025 , Edited by admin on Wed Apr 02 21:17:18 GMT 2025

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FDA UNII

8X769U9BGL

Created by admin on Wed Apr 02 21:17:18 GMT 2025 , Edited by admin on Wed Apr 02 21:17:18 GMT 2025

PRIMARY

INN

13495

Created by admin on Wed Apr 02 21:17:18 GMT 2025 , Edited by admin on Wed Apr 02 21:17:18 GMT 2025

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From	To
1_22	1_95
2_22	2_95
2_142	2_198
2_218	4_214
2_259	2_319
1_142	1_198
2_365	2_423
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_218	3_214
1_224	2_224
1_227	2_227
1_259	1_319
1_365	1_423

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_295
N	2_295

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET->LIGAND

Amount:

Related Record Type Details


					8X769U9BGL

Amdokitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_445] [2_445]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL