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Details

Stereochemistry RACEMIC
Molecular Formula C16H11ClN2O3
Molecular Weight 314.723
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TESICAM

SMILES

ClC1=CC=C(NC(=O)C2C(=O)NC(=O)C3=C2C=CC=C3)C=C1

InChI

InChIKey=HWCORKBTTGTRDY-UHFFFAOYSA-N
InChI=1S/C16H11ClN2O3/c17-9-5-7-10(8-6-9)18-15(21)13-11-3-1-2-4-12(11)14(20)19-16(13)22/h1-8,13H,(H,18,21)(H,19,20,22)

HIDE SMILES / InChI

Molecular Formula C16H11ClN2O3
Molecular Weight 314.723
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Tesicam is a dioxoisoquinoline derivative patented by Pfizer, Chas. and Co., Inc. as an anti-inflammatory agent. In preclinical models, Tesicam shows potent anti-inflammatory activity against carrageenin-induced edema in rats.

Originator

Sources: ZA6803465 "1,​3(2H,​4H)​-​Dioxoisoquinoline-​4-​carboxamides"; Kadin, Saul B.; Nov 11, 1968

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:34:28 GMT 2023
Edited
by admin
on Fri Dec 15 18:34:28 GMT 2023
Record UNII
8X48DWE4EM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TESICAM
INN   USAN  
INN   USAN  
Official Name English
CP-13,608
Code English
CP-13608
Code English
4-ISOQUINOLINECARBOXAMIDE, N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1,3-DIOXO-
Systematic Name English
tesicam [INN]
Common Name English
NSC-355083
Code English
TESICAM [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
Code System Code Type Description
INN
2995
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
NCI_THESAURUS
C152574
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
EVMPD
SUB10934MIG
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
CAS
21925-88-2
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
SMS_ID
100000082734
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID10865021
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
NSC
355083
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
FDA UNII
8X48DWE4EM
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
PUBCHEM
30860
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
ChEMBL
CHEMBL1213365
Created by admin on Fri Dec 15 18:34:28 GMT 2023 , Edited by admin on Fri Dec 15 18:34:28 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY