Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H11ClN2O2 |
| Molecular Weight | 286.7135 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
c1ccc(cc1)C2=N(=O)CC(=Nc3ccc(cc32)Cl)O
InChI
InChIKey=GGRWZBVSUZZMKS-UHFFFAOYSA-N
InChI=1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)
| Molecular Formula | C15H11ClN2O2 |
| Molecular Weight | 286.7135 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Demoxepam is a major pharmacologically active metabolite of the benzodiazepine chlordiazepoxide, the first drug within the class to gain approval by the Food and Drug Administration for use as an anticonvulsant, muscle relaxant and sedative hypnotic. Demoxepam has been shown to have antianxiety activity in man. The eventual elimination of demoxepam from the plasma was slow, with a range in half-life of 14-95 hr. The half-life of demoxepam was markedly longer than that of chlordiazepoxide. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 12:48:09 UTC 2021
by
admin
on
Sat Jun 26 12:48:09 UTC 2021
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| Record UNII |
8X1XP5M0SB
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| Record Status |
Validated (UNII)
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| Record Version |
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| Code System | Code | Type | Description | ||
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CHEMBL1597677
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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DEMOXEPAM
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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2850
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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C171701
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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213-515-2
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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1110020
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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PRIMARY | USP-RS | ||
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8X1XP5M0SB
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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963-39-3
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admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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963-39-3
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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SUB06970MIG
Created by
admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
BINDER->LIGAND |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE ACTIVE |
Chlordiazepoxide-> Norchlordiazepoxide-> Demoxepam
ASSAY (HPLC)
Scientific Literature
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (TLC)
USP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
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ACTIVE MOIETY |
