DEMOXEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H11ClN2O2
Molecular Weight	286.713
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+]1=C(C2=CC=CC=C2)C3=C(NC(=O)C1)C=CC(Cl)=C3

InChI

InChIKey=GGRWZBVSUZZMKS-UHFFFAOYSA-N

InChI=1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)

HIDE SMILES / InChI

Molecular Formula	C15H11ClN2O2
Molecular Weight	286.713
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1627359 | https://www.ncbi.nlm.nih.gov/pubmed/5129365 | https://www.researchgate.net/publication/289313926_Demoxepam | https://www.ncbi.nlm.nih.gov/pubmed/5058629

Demoxepam is a major pharmacologically active metabolite of the benzodiazepine chlordiazepoxide, the first drug within the class to gain approval by the Food and Drug Administration for use as an anticonvulsant, muscle relaxant and sedative hypnotic. Demoxepam has been shown to have antianxiety activity in man. The eventual elimination of demoxepam from the plasma was slow, with a range in half-life of 14-95 hr. The half-life of demoxepam was markedly longer than that of chlordiazepoxide. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei.

Approval Year

PubMed

Title	Date	PubMed
Chlordiazepoxide metabolite accumulation in liver disease.	1989 Jan-Feb	2710011

Sample Use Guides

In Vivo Use Guide

20 mg with a 1 week interval between doses

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Thu Jul 06 02:12:04 UTC 2023` Edited by `admin` on `Thu Jul 06 02:12:04 UTC 2023`
Record UNII	8X1XP5M0SB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEMOXEPAM

Official Name

English

7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide

Systematic Name

English

CHLORDIAZEPOXIDE LACTAM

Common Name

English

7-CHLORO-2,3-DIHYDRO-5-PHENYL-1H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE

Systematic Name

English

5-PHENYL-7-CHLORO-3H-1,4-BENZODIAZEPIN-2(1H)-ONE 4-OXIDE

Systematic Name

English

OXAZEPAM IMPURITY E [EP IMPURITY]

Common Name

English

NSC-169898

Code

English

NSC-46077

Code

English

7-CHLORO-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE

Systematic Name

English

RO 5-2092

Code

English

demoxepam [INN]

Common Name

English

NSC-46007

Code

English

RO-52092

Code

English

CHLORDIAZEPOXIDE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

CHLORDIAZEPOXIDE IMPURITY A [EP IMPURITY]

Common Name

English

RO-5-2092

Code

English

DEMOXEPAM [USAN]

Common Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1,3-DIHYDRO-5-PHENYL-, 4-OXIDE

Systematic Name

English

CHLORDIAZEPOXIDE RELATED COMPOUND A

Common Name

English

CHLORDIAZEPOXIDE RELATED COMPOUND A [USP-RS]

Common Name

English

CHLORDIAZEPOXIDE RELATED COMPOUND A [USP IMPURITY]

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL1597677