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Details

Stereochemistry ACHIRAL
Molecular Formula C15H11ClN2O2
Molecular Weight 286.7135
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEMOXEPAM

SMILES

c1ccc(cc1)C2=N(=O)CC(=Nc3ccc(cc32)Cl)O

InChI

InChIKey=GGRWZBVSUZZMKS-UHFFFAOYSA-N
InChI=1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)

HIDE SMILES / InChI

Molecular Formula C15H11ClN2O2
Molecular Weight 286.7135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Demoxepam is a major pharmacologically active metabolite of the benzodiazepine chlordiazepoxide, the first drug within the class to gain approval by the Food and Drug Administration for use as an anticonvulsant, muscle relaxant and sedative hypnotic. Demoxepam has been shown to have antianxiety activity in man. The eventual elimination of demoxepam from the plasma was slow, with a range in half-life of 14-95 hr. The half-life of demoxepam was markedly longer than that of chlordiazepoxide. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

20 mg with a 1 week interval between doses
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:48:09 UTC 2021
Edited
by admin
on Sat Jun 26 12:48:09 UTC 2021
Record UNII
8X1XP5M0SB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEMOXEPAM
INN   USAN  
USAN   INN  
Official Name English
7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE
Systematic Name English
CHLORDIAZEPOXIDE LACTAM
Common Name English
7-CHLORO-2,3-DIHYDRO-5-PHENYL-1H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE
Systematic Name English
5-PHENYL-7-CHLORO-3H-1,4-BENZODIAZEPIN-2(1H)-ONE 4-OXIDE
Systematic Name English
NSC-169898
Code English
OXAZEPAM SPECIFIED IMPURITY E [EP]
Common Name English
NSC-46077
Code English
7-CHLORO-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE
Systematic Name English
CHLORDIAZEPOXIDE RELATED COMPOUND A [USP]
Common Name English
RO 5-2092
Code English
DEMOXEPAM [INN]
Common Name English
NSC-46007
Code English
RO-52092
Code English
RO-5-2092
Code English
DEMOXEPAM [USAN]
Common Name English
CHLORDIAZEPOXIDE HYDROCHLORIDE IMPURITY A [EP]
Common Name English
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1,3-DIHYDRO-5-PHENYL-, 4-OXIDE
Systematic Name English
CHLORDIAZEPOXIDE HYDROCHLORIDE SPECIFIED IMPURITY A [EP]
Common Name English
CHLORDIAZEPOXIDE RELATED COMPOUND A
USP   USP-RS  
Common Name English
CHLORDIAZEPOXIDE RELATED COMPOUND A [USP-RS]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL1597677
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
WIKIPEDIA
DEMOXEPAM
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
INN
2850
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
NCI_THESAURUS
C171701
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
ECHA (EC/EINECS)
213-515-2
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
USP_CATALOG
1110020
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY USP-RS
FDA UNII
8X1XP5M0SB
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
EPA CompTox
963-39-3
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
CAS
963-39-3
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
EVMPD
SUB06970MIG
Created by admin on Sat Jun 26 12:48:09 UTC 2021 , Edited by admin on Sat Jun 26 12:48:09 UTC 2021
PRIMARY
Related Record Type Details
BINDER->LIGAND
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Chlordiazepoxide-> Norchlordiazepoxide-> Demoxepam
ASSAY (HPLC)
Scientific Literature
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (TLC)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY