PHTHALIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6O2
Molecular Weight	134.132
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1OCC2=C1C=CC=C2

InChI

InChIKey=WNZQDUSMALZDQF-UHFFFAOYSA-N

InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2

HIDE SMILES / InChI

Molecular Formula	C8H6O2
Molecular Weight	134.132
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Runoff of aerially applied phthalide from paddy fields.	2006 Oct	17123009
An alkyne strategy for the asymmetric synthesis of natural products: application to (+)-spirolaxine methyl ether.	2007	17722127
Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry.	2007 Apr	17372865
Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones.	2007 Jun 22	17511506
Reductive dechlorination of chloroethenes by Dehalococcoides-containing cultures enriched from a polychlorinated-dioxin-contaminated microcosm.	2007 Oct	18043649
Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone.	2007 Sep 15	17632002
High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C.	2008 Apr 15	18191462
3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one.	2008 Apr 2	21202272
Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.	2008 Aug	18651584
3-(5,6,7,8-Tetra-hydro-2-naphth-yl)iso-benzofuran-1(3H)-one.	2008 Aug 6	21201685
Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.	2008 Dec	18766378
[GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China].	2008 Feb	18536465
Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.	2008 Jan	18203053
Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.	2008 Jan	17889286
Flavor enhancement of chicken broth from boiled celery constituents.	2008 Jan 23	18163555
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.	2008 Jun 1	18457954
Chemical markers for the quality control of herbal medicines: an overview.	2008 Jun 28	18588699
3-(2,4-Dichloro-anilino)iso-benzo-furan-1(3H)-one.	2008 Mar 29	21202144
3-(2-Chloro-anilino)isobenzofuran-1(3H)-one.	2008 Mar 29	21202143
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-ylamino)benzoic acid.	2008 Mar 29	21202142
Variation of 4,5,6,7-tetrachlorophthalide in water after aerial application to rice cultivation area.	2008 May	18500665
[Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS].	2008 Nov	19149261
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.	2008 Oct	18817445
Decrease of 4,5,6,7-tetrachlorophthalide in paddy field soil after aerial application.	2008 Oct	18670728
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.	2008 Oct 30	18718517
Dynamic nature of the ligustilide complex.	2008 Sep	18781813
New antitumour fungal metabolites from Alternaria porri.	2009	19662571
New phthalide glycosides from Helichrysum arenarium (L.) Moench.	2009	19431016
A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.	2009 Aug	19703351
Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis.	2009 Dec	20407556
Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids.	2009 Dec 4	19873994
Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.	2009 Jul	19504482
Daily variation of pesticides in surface water of a small river flowing through paddy field area.	2009 Jun	19290454
Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.	2009 Jun 21	19503935
Occurence and bioactivities of funicone-related compounds.	2009 Mar 30	19468317
Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.	2009 Mar-Apr	19485194
Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration.	2009 May 8	19344906
Phthalides by rhodium-catalyzed ketone hydroacylation.	2009 Nov 4	19813746
Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions.	2009 Oct 15	19810768
Two new compounds from the roots of Ligusticum chuanxiong.	2009 Sep	20183328
Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.	2010	20686231
Synthesis of demethylated nidulol via an intramolecular Michael reaction.	2010 Aug	20645216
New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalis.	2010 Dec	21139273
A practical total synthesis of (+)-spirolaxine methyl ether.	2010 Dec 3	21058660
Pesticide residues in coastal waters affected by rice paddy effluents temporarily stored in a wastewater reservoir in southern Japan.	2010 Feb	19609592
Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.	2010 Jan 15	20110895
Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.	2010 Jan 15	20000698
Rhodium-catalyzed cascade reaction: aryl addition/intramolecular esterification to access 3-aryl and 3-alkenyl phthalides.	2010 May 10	20391450
Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides.	2010 May 7	20386851
Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.	2010 Sep 3	20795749

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:02:43 GMT 2023` Edited by `admin` on `Fri Dec 15 18:02:43 GMT 2023`
Record UNII	8VV922U86J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PHTHALIDE

Systematic Name

English

NSC-1469

Code

English

PHTHALIDE [FHFI]

Common Name

English

2-BENZOFURAN-1(3H)-ONE

Systematic Name

English

1-PHTHALANONE

Common Name

English

2-HYDROXYMETHYLBENZOIC ACID, .GAMMA.-LACTONE

Common Name

English

PHTHALOLACTONE

Common Name

English

3H-2-BENZOFURAN-1-ONE

Systematic Name

English

FEMA NO. 4195

Code

English

3H-ISOBENZOFURAN-1-ONE

Systematic Name

English

1(3H)-ISOBENZOFURANONE

Systematic Name

English

Code System Code Type Description

ALANWOOD

phthalide