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Details

Stereochemistry ACHIRAL
Molecular Formula C8H6O2
Molecular Weight 134.132
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHTHALIDE

SMILES

O=C1OCC2=CC=CC=C12

InChI

InChIKey=WNZQDUSMALZDQF-UHFFFAOYSA-N
InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2

HIDE SMILES / InChI
Molecular Formula C8H6O2
Molecular Weight 134.132
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
A practical total synthesis of (+)-spirolaxine methyl ether.
2010-12-03
New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalis.
2010-12
Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.
2010-09-03
Synthesis of demethylated nidulol via an intramolecular Michael reaction.
2010-08
Rhodium-catalyzed cascade reaction: aryl addition/intramolecular esterification to access 3-aryl and 3-alkenyl phthalides.
2010-05-10
Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides.
2010-05-07
Pesticide residues in coastal waters affected by rice paddy effluents temporarily stored in a wastewater reservoir in southern Japan.
2010-02
Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.
2010-01-15
Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.
2010-01-15
Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.
2010
Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids.
2009-12-04
Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis.
2009-12
Phthalides by rhodium-catalyzed ketone hydroacylation.
2009-11-04
Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions.
2009-10-15
Two new compounds from the roots of Ligusticum chuanxiong.
2009-09
A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.
2009-08
Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
2009-07
Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.
2009-06-21
Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.
2009-06-03
Daily variation of pesticides in surface water of a small river flowing through paddy field area.
2009-06
Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration.
2009-05-08
Occurence and bioactivities of funicone-related compounds.
2009-03-30
New antitumour fungal metabolites from Alternaria porri.
2009
New phthalide glycosides from Helichrysum arenarium (L.) Moench.
2009
Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.
2008-12
[Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS].
2008-11
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.
2008-10-30
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
2008-10
Decrease of 4,5,6,7-tetrachlorophthalide in paddy field soil after aerial application.
2008-10
Dynamic nature of the ligustilide complex.
2008-09
3-(5,6,7,8-Tetra-hydro-2-naphth-yl)iso-benzofuran-1(3H)-one.
2008-08-06
Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.
2008-08
Chemical markers for the quality control of herbal medicines: an overview.
2008-06-28
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.
2008-06-01
Variation of 4,5,6,7-tetrachlorophthalide in water after aerial application to rice cultivation area.
2008-05
High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C.
2008-04-15
3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one.
2008-04-02
3-(2,4-Dichloro-anilino)iso-benzo-furan-1(3H)-one.
2008-03-29
3-(2-Chloro-anilino)isobenzofuran-1(3H)-one.
2008-03-29
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-ylamino)benzoic acid.
2008-03-29
[GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China].
2008-02
Flavor enhancement of chicken broth from boiled celery constituents.
2008-01-23
Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.
2008-01
Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
2008-01
Reductive dechlorination of chloroethenes by Dehalococcoides-containing cultures enriched from a polychlorinated-dioxin-contaminated microcosm.
2007-10
Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone.
2007-09-15
Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level.
2007-07
Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones.
2007-06-22
Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.
2007-06
An alkyne strategy for the asymmetric synthesis of natural products: application to (+)-spirolaxine methyl ether.
2007
Patents

Patents

03963702
1
JP1024787A
1
JP1026559A
1
JP1029371A
1
JP1038083A
1
JP2006212832A
1
JP2006225306A
1
JP2007246856A
1
JP2011116674A
1
JP2011201818A
1
JP5326349B2
1
JP5356029B2
1
JPH01104692A
1
JPH01289866A
1
JPH02101075A
1
JPH03123778A
1
JPH03157379A
1
JPH04235967A
1
JPH0469325A
1
JPH0477480A
1
JPH05208976A
1
JPH06108044A
1
JPH069311A
1
JPH07268223A
1
JPH07268237A
1
JPH0733747A
1
JPH0776587A
1
JPH08188528A
1
JPH0899813A
8
JPH09263704A
1
JPH10243794A
1
JPH10338684A
1
JPH1044619A
1
JPH1112263A
1
JPS06368505A
1
JPS5289130A
1
JPS5390255A
1
JPS5412366A
1
JPS5430149A
1
JPS55115455A
1
JPS55123651A
1
JPS55151579A
1
JPS55157677A
1
JPS552617A
1
JPS5579375A
1
JPS57167979A
1
JPS63215776A
1
JPS6363648A
1
JPS6368505A
1
JPS6424787A
1
JPS6438083A
1
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:01:06 GMT 2025
Edited
by admin
on Mon Mar 31 19:01:06 GMT 2025
Record UNII
8VV922U86J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHTHALIDE
FHFI  
Systematic Name English
FEMA NO. 4195
Preferred Name English
NSC-1469
Code English
PHTHALIDE [FHFI]
Common Name English
2-BENZOFURAN-1(3H)-ONE
Systematic Name English
1-PHTHALANONE
Common Name English
2-HYDROXYMETHYLBENZOIC ACID, .GAMMA.-LACTONE
Common Name English
PHTHALOLACTONE
Common Name English
3H-2-BENZOFURAN-1-ONE
Systematic Name English
3H-ISOBENZOFURAN-1-ONE
Systematic Name English
1(3H)-ISOBENZOFURANONE
Systematic Name English
Code System Code Type Description
ALANWOOD
phthalide
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
FDA UNII
8VV922U86J
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
WIKIPEDIA
PHTHALIDE
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
ECHA (EC/EINECS)
201-744-0
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
EPA CompTox
DTXSID0052594
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
NSC
1469
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
PUBCHEM
6885
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
CHEBI
38085
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
SMS_ID
100000172253
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
CAS
87-41-2
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
MESH
C082022
Created by admin on Mon Mar 31 19:01:06 GMT 2025 , Edited by admin on Mon Mar 31 19:01:06 GMT 2025
PRIMARY
NIH
NCATS
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