U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Homspera is a synthetic analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species. Substance P has been shown to stimulate cellular growth in cell culture, and it was shown that Substance P could promote wound healing of non-healing ulcers in humans. Homspera to be effective in treating the pulmonary injury as well as mitigating acute effects, including the hematopoietic syndrome, resulting from exposure to ionizing radiation. Homspera to be effective in stimulating human, adult, blood-forming stem cells (hematopoietic stem cells), which have previously been shown to be capable of becoming blood cells that are vital to the body’s immune system. Homspera may have potential benefit in situations where regenerating or stimulating the immune system is desired, as with patients undergoing chemotherapy who may develop leukopenia

Approval Year

Substance Class Protein
Created
by admin
on Mon Mar 31 21:28:11 GMT 2025
Edited
by admin
on Mon Mar 31 21:28:11 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
8V0QAFPRXV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
(SAR9,MET(O2)11)SUBSTANCE P
Common Name English
HOMSPERA
Preferred Name English
SAR9, MET(O2)11-SUBSTANCE P
Common Name English
SUBSTANCE P, 9-(N-METHYLGLYCINE)-11-((2S)-2-AMINO-4-(METHYLSULFONYL)BUTANAMIDE)-
Common Name English
VIPROVEX
Brand Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 304110
Created by admin on Mon Mar 31 21:28:11 GMT 2025 , Edited by admin on Mon Mar 31 21:28:11 GMT 2025
Code System Code Type Description
FDA UNII
8V0QAFPRXV
Created by admin on Mon Mar 31 21:28:11 GMT 2025 , Edited by admin on Mon Mar 31 21:28:11 GMT 2025
PRIMARY
PUBCHEM
163829
Created by admin on Mon Mar 31 21:28:11 GMT 2025 , Edited by admin on Mon Mar 31 21:28:11 GMT 2025
PRIMARY
DRUG BANK
DB05875
Created by admin on Mon Mar 31 21:28:11 GMT 2025 , Edited by admin on Mon Mar 31 21:28:11 GMT 2025
PRIMARY
CAS
110880-55-2
Created by admin on Mon Mar 31 21:28:11 GMT 2025 , Edited by admin on Mon Mar 31 21:28:11 GMT 2025
PRIMARY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_9] GLYCINE Amount: SARCOSINE Z711V88R5F
AMINO ACID SUBSTITUTION [1_11] C-TERMINUS METHIONINE Amount: METHIONINAMIDE (S,S)-DIOXIDE 0O58LJI3XN
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL