2,2,2-Trifluoroethanol

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3F3O
Molecular Weight	100.0398
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(F)(F)F

InChI

InChIKey=RHQDFWAXVIIEBN-UHFFFAOYSA-N

InChI=1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

HIDE SMILES / InChI

Molecular Formula	C2H3F3O
Molecular Weight	100.0398
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions.	2002-05-31	11896058
The chain length dependence of helix formation of the second transmembrane domain of a G protein-coupled receptor of Saccharomyces cerevisiae.	2002-04-26	11854278
NMR conformational analysis of antide, a potent antagonist of the gonadotropin releasing hormone.	2002-04-03	11916429
Expression, purification, and structural characterization of human histone H4.	2002-04	11922758
Product binding to the diiron(III) and mixed-valence diiron centers of methane monooxygenase hydroxylase studied by (1,2)H and (19)F ENDOR spectroscopy.	2002-03-20	11890816
HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56.	2002-03-08	11893391
Influence of backbone conformation on protein aggregation.	2002-03-06	11866599
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides.	2002-03	11932493
Temperature-induced extended helix/random coil transitions in a group 1 late embryogenesis-abundant protein from soybean.	2002-03	11891239
Detecting equilibrium cytochrome c folding intermediates by electrospray ionisation mass spectrometry: two partially folded forms populate the molten-globule state.	2002-03	11847268
Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.	2002-03	11835990
Peptide models of folding initiation sites of bovine beta-lactoglobulin: identification of nativelike hydrophobic interactions involving G and H strands.	2002-02-26	11851426
Anhydrodihydroartemisinin and its 10-trifluoromethyl analogue: access to novel d-ring-contracted artemisinin trifluoromethyl ketones.	2002-02-22	11846670
C [bond] H activation by cationic platinum(II) complexes: ligand electronic and steric effects.	2002-02-20	11841307
Conformational mapping of the N-terminal peptide of HIV-1 gp41 in membrane environments using (13)C-enhanced Fourier transform infrared spectroscopy.	2002-02-15	11853678
An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.	2002-02-15	11850338
Hints of nonhierarchical folding of acidic fibroblast growth factor.	2002-02-12	11827539
Comparison between UV Raman and circular dichroism detection of short alpha helices in bombolitin III.	2002-02-12	11827535
Photosolvolysis of (E)-styryl(phenyl)iodonium tetrafluoroborate. Generation and reactivity of a primary vinyl Cation.	2002-02-08	11856008
Characterization and modelling of the hydrophobic domain of a sunflower oleosin.	2002-02	11925038
Uncoupled analysis of secondary and tertiary protein structure by circular dichroism and electrospray ionization mass spectrometry.	2002-02	11857763
SMAP-29 has two LPS-binding sites and a central hinge.	2002-02	11856344
An inducible helix-Gly-Gly-helix motif in the N-terminal domain of histone H1e: a CD and NMR study.	2002-02	11790831
Human stefin B readily forms amyloid fibrils in vitro.	2002-01-31	11825603
A ruthenium(II) tris(bipyridyl) amino acid: synthesis and direct incorporation into an alpha-helical peptide by solid-phase synthesis.	2002-01-28	11800628
The anti-toxin ParD of plasmid RK2 consists of two structurally distinct moieties and belongs to the ribbon-helix-helix family of DNA-binding proteins.	2002-01-01	11743881
Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with alpha-chiral side chains.	2002-01	11754344
Solvent effect on the isomeric equilibrium of carbohydrates: the superior ability of 2,2,2-trifluoroethanol for intramolecular hydrogen bond stabilization.	2001-12-19	11741425
DNA-induced alpha-helical structure in the NH2-terminal domain of histone H1.	2001-12-07	11584004
Conserved guanine-guanine stacking in tetraplex and duplex DNA.	2001-12	11820398
FTIR studies of intermolecular hydrogen bonding in halogenated ethanols.	2001-12	11789877
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain.	2001-12	11714922
Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).	2001-11-26	11738090
Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis.	2001-11-26	11738089
Conformational changes in pediocin AcH upon vesicle binding and approximation of the membrane-bound structure in detergent micelles.	2001-11-20	11705396
Triethylborane-induced bromine atom-transfer radical addition in aqueous media: study of the solvent effect on radical addition reactions.	2001-11-16	11701036
Unique selectivity of perfluorinated stationary phases with 2,2,2-trifluoroethanol as organic mobile phase modifier.	2001-11-09	11758748
Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in the solution and micelle-associated states.	2001-11-06	11683627
Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides.	2001-11	11892850
N-Terminal domain of HTLV-I integrase. Complexation and conformational studies of the zinc finger.	2001-11	11763363
Calcium-dependent stabilization of the central sequence between Met(76) and Ser(81) in vertebrate calmodulin.	2001-11	11606301
Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.	2001-10-19	11682065
Interrelationships among biological activity, disulfide bonds, secondary structure, and metal ion binding for a chemically synthesized 34-amino-acid peptide derived from alpha-fetoprotein.	2001-10-03	11687299
Acidity of carboxylic acids: a rebuttal and redefinition.	2001-10-03	11572676
Conformation and other biophysical properties of cyclic antimicrobial peptides in aqueous solutions.	2001-10	11606214
Intermolecular (1)H[(19)F] NOEs in studies of fluoroalcohol-induced conformations of peptides and proteins.	2001-10	11567580
The roles of turn formation and cross-strand interactions in fibrillization of peptides derived from the OspA single-layer beta-sheet.	2001-10	11567099
The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles.	2001-08-14	11583156
Effects of salt and denaturant on structure of the amino terminal alpha-helical segment of an antibacterial peptide dermaseptin and its binding to model membranes.	2001-06	11693375
Methylated mono- and di(ethylene glycol)-functionalized beta-sheet forming polypeptides.	2001	11749148

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:49 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:49 GMT 2025`
Record UNII	8T8I76KYF1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIFLUOROETHANOL

Preferred Name

English

2,2,2-Trifluoroethanol

Systematic Name

English

NSC-451

Code

English

ETHANOL, 2,2,2-TRIFLUORO-

Systematic Name

English

TRIFLUOROETHANOL [MI]

Common Name

English

2,2,2-TRIFLUOROETHYL ALCOHOL

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

200-913-6