Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C38H44N2O6 |
| Molecular Weight | 624.7658 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C2[C@@H](CC3=CC=C(OC4=CC(C[C@H]5N(C)CCC6=CC(OC)=C(OC)C=C56)=CC=C4O)C=C3)N(C)CCC2=C1
InChI
InChIKey=AQASRZOCERRGBL-ROJLCIKYSA-N
InChI=1S/C38H44N2O6/c1-39-15-13-26-20-35(42-3)37(44-5)22-29(26)31(39)17-24-7-10-28(11-8-24)46-34-19-25(9-12-33(34)41)18-32-30-23-38(45-6)36(43-4)21-27(30)14-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1
| Molecular Formula | C38H44N2O6 |
| Molecular Weight | 624.7658 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. | 2010-11-16 |
|
| Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. | 2010-10 |
|
| Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. | 2010-07-25 |
|
| Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-performance counter-current chromatography. | 2010-07-15 |
|
| [Studies on the chemical constituents of Callicarpa kochiana]. | 2010-06 |
|
| Validated liquid chromatography-tandem mass spectrometry method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study. | 2010-05-01 |
|
| Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice. | 2010-03 |
|
| Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: involvement of Bcl-2 family proteins. | 2010 |
|
| Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current. | 2009-11 |
|
| Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. | 2009-05 |
|
| Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1alpha protein accumulation and vascular endothelial growth factor expression in human breast cancer cells. | 2009-05 |
|
| [Effect of dauricine on apoptosis and expression of apoptogenic protein after transient focal cerebral ischemia-reperfusion injury in rats]. | 2009-01 |
|
| Improved RP-HPLC method to determine neferine in dog plasma and its application to pharmacokinetics. | 2007-10-01 |
|
| Genetic and alkaloid analysis of Menispermum dauricum DC. by RAPD and HPLC. | 2007-07-13 |
|
| Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. | 2007-07-01 |
|
| Neuroprotective effect of dauricine in cortical neuron culture exposed to hypoxia and hypoglycemia: involvement of correcting perturbed calcium homeostasis. | 2007-06 |
|
| Neuroprotective effects of dauricine against apoptosis induced by transient focal cerebral ischaemia in rats via a mitochondrial pathway. | 2007-03 |
|
| Inhibitory effect of dauricine on inflammatory process following focal cerebral ischemia/reperfusion in rats. | 2007 |
|
| [Study on the chemical constituents of Mitragyna rotundifolia]. | 2006-06 |
|
| [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]. | 2005-10 |
|
| Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell. | 2004-12 |
|
| [Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats]. | 2004-08 |
|
| Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. | 2003-10 |
|
| Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. | 2002-12 |
|
| Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. | 2002-07 |
|
| Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier. | 2002-05 |
|
| Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ. | 2002-04 |
|
| [Poteintation of vincristine-induced apoptosis by tetrandrine, neferine and dauricine in the human mammary MCF-7 multidrug-resistant cells]. | 2001-02 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:54:17 GMT 2025
by
admin
on
Mon Mar 31 19:54:17 GMT 2025
|
| Record UNII |
8QTO90G5W5
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
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| Name | Type | Language | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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Dauricine
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C035934
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DTXSID90966808
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524-17-4
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m4105
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PRIMARY | Merck Index | ||
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4331
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73400
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36413
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8QTO90G5W5
Created by
admin on Mon Mar 31 19:54:17 GMT 2025 , Edited by admin on Mon Mar 31 19:54:17 GMT 2025
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PRIMARY |