U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Astodrimer, also known as SPL7013, a microbicide developed by Starpharm. This drug has been used in phase III clinical trials for the treatment and prevention of Bacterial Vaginosis. Starpharma conducts a meeting with US FDA related to potential approval of astodrimer in Bacterial vaginosis. In addition, SPL7013, participated in phase II clinical trials against human immunodeficiency virus (HIV) and herpes simplex virus 2 (genital herpes, HSV-2). It is known that astodrimer binds tightly to R5 gp120 in the gp120-CD4 complex, thus preventing the accrual of the requisite number of gp120-CD4 complexes across the virus-cell interface, thereby blocking virus entry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques.
2005 Mar
SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans.
2011
The SPL7013 dendrimer destabilizes the HIV-1 gp120-CD4 complex.
2015 Nov 28

Sample Use Guides

1% SPL7013 (ASTODRIMER) vaginal gel, daily for 7 days
Route of Administration: Vaginal
Substance Class Protein
Created
by admin
on Sat Dec 16 09:53:55 GMT 2023
Edited
by admin
on Sat Dec 16 09:53:55 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
8Q3B8SV59L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASTODRIMER SODIUM
WHO-DD  
USAN  
Official Name English
Astodrimer sodium [WHO-DD]
Common Name English
SPL-7013 SODIUM
Code English
TETRAHEXACONTASODIUM N2,N6-BIS(N2,N6-BIS(N2,N6-BIS(N2,N6-BIS(N2,N6-BIS((3,6- DISULFONAPHTHALEN-1-YLOXY)ACETYL)-L-LYSYL)-L-LYSYL)-L-LYSYL)-L-LYSYL)- N1-(DIPHENYLMETHYL)-L-LYSINAMIDE
Common Name English
BRI7013 SODIUM
Code English
BRI-7013 SODIUM
Code English
6436
Code English
ASTODRIMER SODIUM [USAN]
Common Name English
Code System Code Type Description
SMS_ID
300000021737
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
DRUG BANK
DBSALT002095
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL2364666
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
MESH
C480351
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
FDA UNII
8Q3B8SV59L
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
NCI_THESAURUS
C188539
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
USAN
ZZ-169
Created by admin on Sat Dec 16 09:53:55 GMT 2023 , Edited by admin on Sat Dec 16 09:53:55 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL