Astodrimer, also known as SPL7013, a microbicide developed by Starpharm. This drug has been used in phase III clinical trials for the treatment and prevention of Bacterial Vaginosis. Starpharma conducts a meeting with US FDA related to potential approval of astodrimer in Bacterial vaginosis. In addition, SPL7013, participated in phase II clinical trials against human immunodeficiency virus (HIV) and herpes simplex virus 2 (genital herpes, HSV-2). It is known that astodrimer binds tightly to R5 gp120 in the gp120-CD4 complex, thus preventing the accrual of the requisite number of gp120-CD4 complexes across the virus-cell interface, thereby blocking virus entry.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. | 2005 Mar |
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| SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans. | 2011 |
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| The SPL7013 dendrimer destabilizes the HIV-1 gp120-CD4 complex. | 2015 Nov 28 |
| Substance Class |
Protein
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| Protein Sub Type | |
| Sequence Type | COMPLETE |
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8Q3B8SV59L
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Validated (UNII)
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DBSALT002095
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CHEMBL2364666
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C480351
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8Q3B8SV59L
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C188539
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| Linkage Type | Residue Index | ||||
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| AMIDE BOND | 16_1 | 1_5 | 2_4 | 4_3 | 8_2 |
| AMIDE BOND | 1_4 | 3_3 | 7_2 | 15_1 | |
| amide bridge | 2_3 | 6_2 | 14_1 | ||
| amide bridge | 4_2 | 12_1 | |||
| amide bridge | 3_2 | 11_1 | |||
| amide bridge | 2_2 | 10_1 | |||
| amide bridge | 1_2 | 9_1 | |||
| amide bridge | 1_3 | 5_2 | 13_1 |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| Molecular Formula | CHEMICAL |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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