U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H34O3S
Molecular Weight 402.59
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SPIROXASONE

SMILES

[H][C@@]12CC[C@@]3(CCCO3)[C@@]1(C)CC[C@@]4([H])[C@@]2([H])[C@@H](CC5=CC(=O)CC[C@]45C)SC(C)=O

InChI

InChIKey=XKCGICBTWRNUCL-KIEAKMPYSA-N
InChI=1S/C24H34O3S/c1-15(25)28-20-14-16-13-17(26)5-9-22(16,2)18-6-10-23(3)19(21(18)20)7-11-24(23)8-4-12-27-24/h13,18-21H,4-12,14H2,1-3H3/t18-,19-,20+,21+,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula C24H34O3S
Molecular Weight 402.59
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Spiroxasone is a synthetic, steroidal antimineralocorticoid of the spirolactone group patented by Merck & Co., Inc. as a diuretic and antihypertensive agent. Spiroxasone acts as potent aldosterone antagonists in animals and humans.

Approval Year

PubMed

PubMed

TitleDatePubMed
ALDOSTERONE ANTAGONISTS. 2'3'-ALPHA-TETRAHYDROFURAN-2'SPIRO-17-(4-ANDROSTEN-3-ONE) AND RELATED COMPOUNDS.
1963 Sep
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:25:33 GMT 2023
Edited
by admin
on Fri Dec 15 18:25:33 GMT 2023
Record UNII
8P0U2ZA1NQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPIROXASONE
INN   USAN  
INN   USAN  
Official Name English
SPIRO(ANDROST-4-ENE-17,2'(3'H)-FURAN)-3-ONE, 2-(ACETYLTHIO)-4',5'-DIHYDRO-, (7.ALPHA.,17.BETA.)-
Common Name English
SPIROXASONE [USAN]
Common Name English
spiroxasone [INN]
Common Name English
4',5'-DIHYDRO-7.ALPHA.-MERCAPTOSPIRO(ANDROST-4-ENE-17,2'-(3'H)-FURAN)-3-ONE ACETATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C101255
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
Code System Code Type Description
SMS_ID
100000083810
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105514
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
FDA UNII
8P0U2ZA1NQ
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
EVMPD
SUB10634MIG
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID101024404
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
CAS
6673-97-8
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
WIKIPEDIA
Spiroxasone
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
INN
1748
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
NCI_THESAURUS
C152421
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
PUBCHEM
23141
Created by admin on Fri Dec 15 18:25:33 GMT 2023 , Edited by admin on Fri Dec 15 18:25:33 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY