Givastomig

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:26:16 GMT 2023` Edited by `admin` on `Sat Dec 16 18:26:16 GMT 2023`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	8MSM5N7RMK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Givastomig

Official Name

English

givastomig [INN]

Common Name

English

Immunoglobulin G1 [300-alanine], anti-(claudin CLDN18.2) (human-Mus musculus γ1-chain) fusion protein with peptide linker ((GGGGS)3) fusion protein with immunoglobulin anti-(tumor necrosis factor receptor TNFRSF9) (human-Mus musculus single-chain variab

Common Name

English

Immunoglobulin G1-scFv_L-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, SFTPJ, surfactant associated protein J)isoform 2, extracellular domain 1 (EC1)], anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T cell antigen ILA,

Common Name

English

Fused G1-scFv lambda-heavy chain humanized (1-716) [gamma1 heavy chain anti-CLDN18 humanized (1-450) [VH (Homo sapiens IGHV1-3*01 (85.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120)-Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1,

Common Name

English

Code System Code Type Description

INN

12650

Created by admin on Sat Dec 16 18:26:16 GMT 2023 , Edited by admin on Sat Dec 16 18:26:16 GMT 2023

PRIMARY

FDA UNII

8MSM5N7RMK

Created by admin on Sat Dec 16 18:26:16 GMT 2023 , Edited by admin on Sat Dec 16 18:26:16 GMT 2023

PRIMARY

CAS

2762499-30-7

Created by admin on Sat Dec 16 18:26:16 GMT 2023 , Edited by admin on Sat Dec 16 18:26:16 GMT 2023

PRIMARY

From	To
4_140	4_200
4_23	4_94
3_140	3_200
3_23	3_94
2_617	2_691
2_568	2_639
2_487	2_554
2_370	2_428
2_264	2_324
2_223	4_220
2_147	2_203
2_22	2_96
1_617	1_691
1_568	1_639
1_487	1_554
1_370	1_428
1_264	1_324
1_232	2_232
1_229	2_229
1_223	3_220
1_147	1_203
1_22	1_96