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Details

Stereochemistry ACHIRAL
Molecular Formula NO3.Na
Molecular Weight 84.9947
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM NITRATE

SMILES

[Na+].[O-][N+]([O-])=O

InChI

InChIKey=VWDWKYIASSYTQR-UHFFFAOYSA-N
InChI=1S/NO3.Na/c2-1(3)4;/q-1;+1

HIDE SMILES / InChI
Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Not Provided
504
MAXIMUM STRENGTH SENSITIVE TRUE MINT

Approved Use

builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact; helps protect against cavities.

Launch Date

1.25176316E12
PubMed

PubMed

TitleDatePubMed
Proton translocation and the respiratory nitrate reductase of Escherichia coli.
1975 Dec
Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine.
1982 Feb
[Acute and chronic cardiac decompensation: is vasodilator therapy useful?].
1982 Jan 14
Calcium antagonists.
1985
Addition of nifedipine to maximal nitrate and beta-adrenoreceptor blocker therapy in coronary artery disease.
1985 May 1
Drug-induced torsade de pointes.
1985 Nov-Dec
Nitrates in acute myocardial infarction.
1987
[Anti-angina therapy of coronary heart disease. Mono- or combination treatment].
1991 May
Therapy of angina pectoris with long-acting nitrates: which agent and when?
1996 May
Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection.
1997 Jul-Aug
Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis.
1997 May
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide.
1997 May
The assimilatory nitrate reductase from the phototrophic bacterium, Rhodobacter capsulatus E1F1, is a flavoprotein.
1997 Sep 1
Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP.
1999 Jan 5
[Nitrate contaminated drinking water from private wells has an impact on the size and functional state of the thyroid gland in schoolchildren].
2000 Nov
[Upper gastrointestinal tract injury caused by ingestion of caustic substances].
2001 Apr
Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture.
2001 Jun
Acute gastric perforation after acid ingestion.
2002 Sep
Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide.
2004 Jul
Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis.
2004 Oct 8
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004 Sep
Effects of various antioxidants on endotoxin-induced lung injury and gene expression: mRNA expressions of MnSOD, interleukin-1beta and iNOS.
2004 Sep 30
Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration.
2005
Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids.
2005 Aug
[Clinical observation on acupuncture combined with medication for intractable angina pectoris].
2005 Feb
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
2005 Feb 1
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
2005 Jan 10
Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.
2005 Jul-Sep
Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliterans.
2005 Nov-Dec
Cl- interference with the epithelial Na+ channel ENaC.
2005 Sep 9
Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium.
2006
Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats.
2006 Jul
Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model.
2006 Jul-Aug
Modifications of inflammatory pathways in rat intestine following chronic ingestion of depleted uranium.
2007 Aug
Oxidative and nitrosative stress in acute ischaemic stroke.
2007 Jan
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007 Oct
Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection.
2007 Winter
Acute lung injury after inhalation of nitric acid.
2008 Dec
Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline.
2008 May
An unusual circumstance of internal chemical burn injury - a case report.
2008 Oct
Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.
2008 Sep
Water disinfection by-products and pre-labor rupture of membranes.
2008 Sep 1
Management of unusually extensive esophagogastric corrosive injuries: emergency measures and gastric reconstruction.
2009 May
The nitric acid burn trauma of the skin.
2010 Apr
Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease.
2010 Jan
Fatal pulmonary edema after acute occupational exposure to nitric acid.
2010 Jul
Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants.
2010 Sep
Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.
2011 Jan
Fine particulate matter constituents and cardiopulmonary mortality in a heavily polluted Chinese city.
2012 Mar
NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.
2014
Patents

Patents

03931177
6
03957791
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03973039
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03978092
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03987186
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03988268
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03992446
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03994968
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04005219
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04010201
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04021479
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04036838
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04038405
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04049705
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04053479
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04055411
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04066651
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04066830
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04067993
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04071524
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04093446
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04096337
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04107315
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04118461
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04120899
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04126444
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04136192
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04141990
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04154941
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04159273
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04166119
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04174342
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04174397
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04177057
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04178387
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04180572
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04180679
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04196120
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04199586
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04200640
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04279918
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04415752
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04555386
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04604267
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04652559
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05292387
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05300511
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05616586
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05633248
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05739129
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05965679
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05972136
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06531502
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06972286
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07029504
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07495021
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08106064
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08394837
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08629277
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08735322
6
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:31:52 UTC 2023
Edited
by admin
on Fri Dec 15 15:31:52 UTC 2023
Record UNII
8M4L3H2ZVZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM NITRATE
FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
INS NO.251
Code English
SODIUM NITRATE [MART.]
Common Name English
SODIUM NITRATE [II]
Common Name English
NSC-77390
Code English
INS-251
Code English
SODIUM NITRATE [VANDF]
Common Name English
SODIUM NITRATE [FCC]
Common Name English
SODIUM NITRATE [MI]
Common Name English
NATRUM NITRICUM
HPUS  
Common Name English
NATRUM NITRICUM [HPUS]
Common Name English
CUBIC NITER
Common Name English
CHILE SALTPETER
Common Name English
NITRIC ACID SODIUM SALT (1:1)
Common Name English
Sodium nitrate [WHO-DD]
Common Name English
SODA NITER
Common Name English
SODIUM NITRATE [INCI]
Common Name English
SODIUM NITRATE [HSDB]
Common Name English
E-251
Code English
Classification Tree Code System Code
JECFA EVALUATION INS-251
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
DSLD 3148 (Number of products:16)
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
EPA PESTICIDE CODE 76104
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
CFR 21 CFR 172.170
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-251
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 569
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
Code System Code Type Description
WIKIPEDIA
SODIUM NITRATE
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY
MERCK INDEX
m10048
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY Merck Index
NSC
77390
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY
MESH
C031618
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PRIMARY
PUBCHEM
24268
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PRIMARY
CHEBI
63005
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PRIMARY
NCI_THESAURUS
C84161
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PRIMARY
FDA UNII
8M4L3H2ZVZ
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PRIMARY
RXCUI
36700
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PRIMARY RxNorm
EPA CompTox
DTXSID6020937
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PRIMARY
NCI_THESAURUS
C45678
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CONCEPT Industrial Aid
EVMPD
SUB15307MIG
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PRIMARY
ECHA (EC/EINECS)
231-554-3
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PRIMARY
DAILYMED
8M4L3H2ZVZ
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY
CAS
7631-99-4
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY
HSDB
726
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PRIMARY
SMS_ID
100000078137
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PRIMARY
RS_ITEM_NUM
1614432
Created by admin on Fri Dec 15 15:31:52 UTC 2023 , Edited by admin on Fri Dec 15 15:31:52 UTC 2023
PRIMARY
Related Record Type Details
Structure of NITRATE ION
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