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Details

Stereochemistry ACHIRAL
Molecular Formula NO3.Na
Molecular Weight 84.9947
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM NITRATE

SMILES

N(=O)(=O)[O-].[Na+]

InChI

InChIKey=VWDWKYIASSYTQR-UHFFFAOYSA-N
InChI=1S/NO3.Na/c2-1(3)4;/q-1;+1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
MAXIMUM STRENGTH SENSITIVE TRUE MINT

Approved Use

builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact; helps protect against cavities.

Launch Date

1251763200000
PubMed

PubMed

TitleDatePubMed
Nitrate reductase from Achromobacter fischeri; purification and properties: function of flavines and cytochrome.
1957 Mar
Proton translocation and the respiratory nitrate reductase of Escherichia coli.
1975 Dec
Electrophysiologic properties of hydralazine in man.
1980 Sep
Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine.
1982 Feb
[Acute and chronic cardiac decompensation: is vasodilator therapy useful?].
1982 Jan 14
Calcium antagonists.
1985
Addition of nifedipine to maximal nitrate and beta-adrenoreceptor blocker therapy in coronary artery disease.
1985 May 1
Drug-induced torsade de pointes.
1985 Nov-Dec
Nitrates in acute myocardial infarction.
1987
[Drug treatment of myocardial ischemia].
1991
[Anti-angina therapy of coronary heart disease. Mono- or combination treatment].
1991 May
Effects of amlodipine on myocardial infarction, infarct expansion, and ventricular geometry in the rat.
1992 Sep
Transient reversal of blood flow in an internal thoracic artery to coronary artery graft during syncope.
1994 Aug
Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells.
1996 Feb 5
Therapy of angina pectoris with long-acting nitrates: which agent and when?
1996 May
Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection.
1997 Jul-Aug
Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis.
1997 May
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide.
1997 May
The assimilatory nitrate reductase from the phototrophic bacterium, Rhodobacter capsulatus E1F1, is a flavoprotein.
1997 Sep 1
Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP.
1999 Jan 5
Platelet nitric oxide metabolites in migraine.
1999 May
[Nitrate contaminated drinking water from private wells has an impact on the size and functional state of the thyroid gland in schoolchildren].
2000 Nov
Diltiazem-mediated inhibition of sildenafil metabolism may promote nitrate-induced hypotension.
2000 Oct
Biphasic alterations in gastrointestinal transit following endotoxaemia in mice.
2001 Dec
Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study.
2001 May
Gallium nitrate accelerates partial thickness wound repair and alters keratinocyte integrin expression to favor a motile phenotype.
2002 Apr
Assessing nitrate metabolism in the intestinal tract by measuring breath nitric oxide and nitrous oxide, and its clinical significance.
2002 May 7
Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid.
2003
Raised nitrate concentration and low SOD activity in the CSF of sporadic ALS patients.
2003 May
Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide.
2004 Jul
Nitrification by plants that also fix nitrogen.
2004 Jul 1
Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride.
2004 Oct 1
Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis.
2004 Oct 8
Effects of various antioxidants on endotoxin-induced lung injury and gene expression: mRNA expressions of MnSOD, interleukin-1beta and iNOS.
2004 Sep 30
Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration.
2005
Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids.
2005 Aug
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
2005 Jan 10
Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.
2005 Jul-Sep
Cl- interference with the epithelial Na+ channel ENaC.
2005 Sep 9
Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats.
2006 Jul
Modifications of inflammatory pathways in rat intestine following chronic ingestion of depleted uranium.
2007 Aug
Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline.
2008 May
Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.
2008 Sep
Water disinfection by-products and pre-labor rupture of membranes.
2008 Sep 1
The nitric acid burn trauma of the skin.
2010 Apr
Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease.
2010 Jan
Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants.
2010 Sep
Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.
2011 Jan
Fine particulate matter constituents and cardiopulmonary mortality in a heavily polluted Chinese city.
2012 Mar
NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.
2014
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:16:24 UTC 2021
Edited
by admin
on Sat Jun 26 01:16:24 UTC 2021
Record UNII
8M4L3H2ZVZ
Record Status Validated (UNII)
Record Version
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Name Type Language
SODIUM NITRATE
FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
INS NO.251
Code English
SODIUM NITRATE [MART.]
Common Name English
SODIUM NITRATE [II]
Common Name English
NSC-77390
Code English
INS-251
Code English
SODIUM NITRATE [VANDF]
Common Name English
SODIUM NITRATE [FCC]
Common Name English
SODIUM NITRATE [MI]
Common Name English
NATRUM NITRICUM
HPUS  
Common Name English
NATRUM NITRICUM [HPUS]
Common Name English
CUBIC NITER
Common Name English
CHILE SALTPETER
Common Name English
SODIUM NITRATE [WHO-DD]
Common Name English
NITRIC ACID SODIUM SALT (1:1)
Common Name English
SODA NITER
Common Name English
SODIUM NITRATE [INCI]
Common Name English
SODIUM NITRATE [HSDB]
Common Name English
E-251
Code English
Classification Tree Code System Code
JECFA EVALUATION INS-251
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
DSLD 3148 (Number of products:16)
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
EPA PESTICIDE CODE 76104
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
CFR 21 CFR 172.170
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-251
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 569
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
Code System Code Type Description
WIKIPEDIA
SODIUM NITRATE
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
MERCK INDEX
M10048
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY Merck Index
MESH
C031618
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
PUBCHEM
24268
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
NCI_THESAURUS
C84161
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
JECFA MONOGRAPH
INS-251
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
FDA UNII
8M4L3H2ZVZ
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
RXCUI
36700
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY RxNorm
EPA CompTox
7631-99-4
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
CONCEPT Industrial Aid
EVMPD
SUB15307MIG
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
ECHA (EC/EINECS)
231-554-3
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
CAS
7631-99-4
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
HSDB
726
Created by admin on Sat Jun 26 01:16:24 UTC 2021 , Edited by admin on Sat Jun 26 01:16:24 UTC 2021
PRIMARY
Related Record Type Details
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