OLPASIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 00:12:20 GMT 2025` Edited by `admin` on `Wed Apr 02 00:12:20 GMT 2025`
Nucleic Acid Type	SIRNA
Sequence Type	COMPLETE
Record UNII	8M4GC1EOB4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OLPASIRAN

Official Name

English

AMG 890

Preferred Name

English

ALL-P-AMBO-5'-O-((25S,30S)-39-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-25,30-BIS((2-(2-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHYL)CARBAMOYL)-1,23,28,33-TETRAOXO-1-SULFANYL-2,5,8,11,14,17,20,37-OCTAOXA-24,29,34-TRIAZA-1.L

Common Name

English

OLPASIRAN [USAN]

Common Name

English

Olpasiran [WHO-DD]

Common Name

English

RNA, (CM-SP-AM-GM-CM-CM-CM-CM-UM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'-FLUORO)U-UM-GM-UM-UM-AM-UM-AM-CM-GM-(3'->3')-SP-DA), 5'-(O-((23S,28S)-37-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-23,28-BIS(((2-(2-((2-(ACETYLAMINO)

Common Name

English

olpasiran [INN]

Common Name

English

AMG-890

Code

English

Code System Code Type Description

SMS_ID

300000016920

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

INN

11099

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

FDA UNII

8M4GC1EOB4

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

USAN

HI-240

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

CAS

2225856-03-9

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

NCI_THESAURUS

C175176

Created by admin on Wed Apr 02 00:12:20 GMT 2025 , Edited by admin on Wed Apr 02 00:12:20 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_8;1_12-1_20;2_1;2_3;2_5;2_7-2_11;2_13;2_15;2_17;2_19;2_21	30 / 42
2'-Fluoro-Ribose	1_9-1_11;2_2;2_4;2_6;2_12;2_14;2_16;2_18;2_20	11 / 42
Deoxyribose (DNA)	1_21	1 / 42

Linkage	Site Range	Site Count
Phosporothioate	1_2;1_21;2_2-2_3;2_20-2_21	6 / 40
Phosphate	1_3-1_20;2_4-2_19	34 / 40

Related Record Type Details


					8M4GC1EOB4

OLPASIRAN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	e876bd0a (not in database)
NUCLEOTIDE SUBSTITUTION	[1_21]	3'-TERMINUS			DEOXYADENOSINE-3'-MONOPHOSPHATE	M66274TJJ6