Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H28FNO5 |
| Molecular Weight | 464.5159 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(OCC[18F])C=C2)C3=C(C=CC=C3)N=C1C4CC4)CC(O)=O
InChI
InChIKey=SPOCALKCBUKFRC-LGHSKKJBSA-N
InChI=1S/C27H28FNO5/c28-13-14-34-21-10-7-17(8-11-21)26-22-3-1-2-4-24(22)29-27(18-5-6-18)23(26)12-9-19(30)15-20(31)16-25(32)33/h1-4,7-12,18-20,30-31H,5-6,13-16H2,(H,32,33)/b12-9+/t19-,20-/m1/s1/i28-1
| Molecular Formula | C27H28FNO5 |
| Molecular Weight | 464.5159 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:34:44 GMT 2025
by
admin
on
Mon Mar 31 22:34:44 GMT 2025
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| Record UNII |
8LSL2H7TXM
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| Record Status |
Validated (UNII)
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| Record Version |
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66556690
Created by
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1398394-11-0
Created by
admin on Mon Mar 31 22:34:44 GMT 2025 , Edited by admin on Mon Mar 31 22:34:44 GMT 2025
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8LSL2H7TXM
Created by
admin on Mon Mar 31 22:34:44 GMT 2025 , Edited by admin on Mon Mar 31 22:34:44 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Results: (18F)PTV-F1 was produced in about 80 minutes with radioactivity of 4.9+/-1.4 GBq, radiochemical yield (decay uncorrected) of 25.0+/-3.6%, radiochemical purity of >98.1% and specific activity of 197.2+/-49.3 GBq/undefinedmol. The products meet the relevant quality standard such as the Quality Control of (18F)FDG. The reference compound was tested for toxicity in the mice. The effective dose for the adult dosimetric model was estimated to be 0.0121 mSv/MBq using OLINDA/EXM 1.1.
Conclusions: On this cassette-type multipurpose automatic synthesizer module, the synthesis of (18F)PTV-F1 for clinical grade was successfully implemented in our first-in-man study with healthy volunteers.
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