Tegrenmeran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 18:09:41 GMT 2025` Edited by `admin` on `Wed Apr 02 18:09:41 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Origin	VIRAL
Sequence Type	COMPLETE
Record UNII	8JTY7VW9J8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tegrenmeran

Official Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Am)-capped severe acute respiratory syndrome coronavirus 2 B.1.1.529.4 and B.1.1.529.5 variant (1-13)-(319-541)-spike glycoprotein precursor plus human ?-globin 5?-and 3?-untranslated flanking region-containing poly(A

Preferred Name

English

tegrenmeran [INN]

Common Name

English

messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein (Omicron sub-lineages B.1.1.529.4 (BA.4) and B.1.1.529.5 (BA.5); based

Common Name

English

Code System Code Type Description

FDA UNII

8JTY7VW9J8

Created by admin on Wed Apr 02 18:09:41 GMT 2025 , Edited by admin on Wed Apr 02 18:09:41 GMT 2025

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CAS

2889466-36-6

Created by admin on Wed Apr 02 18:09:41 GMT 2025 , Edited by admin on Wed Apr 02 18:09:41 GMT 2025

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INN

13092

Created by admin on Wed Apr 02 18:09:41 GMT 2025 , Edited by admin on Wed Apr 02 18:09:41 GMT 2025

PRIMARY

NCI_THESAURUS

C203098

Created by admin on Wed Apr 02 18:09:41 GMT 2025 , Edited by admin on Wed Apr 02 18:09:41 GMT 2025

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SMS_ID

300000053751

Created by admin on Wed Apr 02 18:09:41 GMT 2025 , Edited by admin on Wed Apr 02 18:09:41 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_1018	1018 / 1018

Linkage	Site Range	Site Count
Phosphate	1_2-1_1018	1017 / 1017

Related Record Type Details


					K8L29Q5JHJ

Tegrenmeran expressed preprotein (receptor binding domain (RBD) of the spike glycoprotein from Omicron variants BA.4/5 with C233S)

EXPRESSED PROTEIN->VECTOR

Amount:


					97T55W4MRW

Tegrenmeran expressed receptor binding domain (RBD) of the spike glycoprotein from Omicron variants BA.4/5 with C233S

EXPRESSED PROTEIN->VECTOR

Amount:


					B6L4N5Z4GH

SARS-COV2

TARGET ORGANISM->VACCINE ANTIGEN

Amount:

Related Record Type Details


					8JTY7VW9J8

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			7M-G-PPP-2'M-A-P MRNA CAP	P7W5ZN6FY2
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	U		THYMINE	QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	C		5-METHYLCYTOSINE	6R795CQT4H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Poly (A) tail	NUCLEIC ACID FEATURE
Coding sequence	NUCLEIC ACID FEATURE
3’-untranslated region (UTR)	NUCLEIC ACID FEATURE
5'-untranslated region (UTR)	NUCLEIC ACID FEATURE