3-AMINOBENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N2O
Molecular Weight	136.1512
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CC(N)=CC=C1

InChI

InChIKey=GSCPDZHWVNUUFI-UHFFFAOYSA-N

InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H8N2O
Molecular Weight	136.1512
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Poly (ADP-ribose) polymerase (Sus scrofa) 1 Target ID: Poly (ADP-ribose) polymerase (Sus scrofa) Sources: https://www.ncbi.nlm.nih.gov/pubmed/6248035	Inhibitor 8297		1.8 µM [Ki]

PubMed

Title	Date	PubMed
Apoptosis inhibitors delay the cytopathic effect of bovine viral diarrhoea virus (BVDV).	2002 Aug	12241032
Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.	2002 Aug	12234774
The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.	2002 Aug	12220950
Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism.	2002 Aug	12154007
Bench-to-bedside review: Cytopathic hypoxia.	2002 Dec	12493070
Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.	2002 Dec	12490035
Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.	2002 Dec	12454457
Poly(Adp-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm.	2002 Jul	12208123
tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator.	2002 Jul	12110167
Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury.	2002 Jul	12091461
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.	2002 Jul 15	12140175
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.	2002 May-Jun	12628304
The effect of H2O2 and tertiary butyl hydroperoxide upon a murine immortal lens epithelial cell line, alphaTN4-1.	2002 Nov	12457869
Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase.	2002 Nov	12412622
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.	2002 Oct	12237842
Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide, an inhibitior of parp enzyme.	2002 Oct 31	12379459
Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice.	2002 Oct 31	12379458
The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.	2002 Sep	12169758
Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.	2003	14580948
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.	2003	14520006
Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.	2003 Aug	14580150
The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells.	2003 Aug	12867996
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.	2003 Aug	12824290
The effect of PARS inhibition on ileal histopathology, apoptosis and lipid peroxidation in LPS-induced obstructive jaundice.	2003 Aug	12798666
The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells.	2003 Dec	14612922
Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation.	2003 Dec	14514653
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.	2003 Feb	12663936
Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.	2003 Feb	12576936
gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells.	2003 Feb 17	12581860
Oxidant-induced cell death in renal epithelial cells: differential effects of inorganic and organic hydroperoxides.	2003 Jan	12710597
Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.	2003 Jan	12619896
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.	2003 Jan	12488552
Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.	2003 Jan 15	12509801
Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.	2003 Jul	12897815
Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.	2003 Jul 16	12866953
Hsp70 attenuates hypoxia/reoxygenation-induced activation of poly(ADP-ribose) synthetase in the nucleus of adult rat cardiomyocytes.	2003 Jun	12870667
Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells.	2003 Jun	12753082
Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.	2003 Mar	12688429
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.	2003 Mar	12594058
Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.	2003 Mar 7	12506112
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.	2003 May	12686864
Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.	2003 May	12621128
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.	2003 May 23	12782201
Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.	2003 Nov	12871856
Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion.	2003 Oct	12964031
Cellular events involved in butyric acid-induced T cell apoptosis.	2003 Oct 1	14500654
Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells.	2003 Oct 15	14556861
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.	2003 Oct 22	14594650
Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat.	2003 Oct 31	14519512
Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells.	2003 Sep	12957467

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:35:39 UTC 2023` Edited by `admin` on `Fri Dec 15 17:35:39 UTC 2023`
Record UNII	8J365YF1YH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3-AMINOBENZAMIDE

Systematic Name

English

(3-(AMINOCARBONYL)PHENYL)AMINE

Systematic Name

English

3-(AMINOCARBONYL)ANILINE

Systematic Name

English

BENZAMIDE, 3-AMINO-

Systematic Name

English

NSC-36962

Code

English

M-AMINOBENZAMIDE

Systematic Name

English

3-CARBOXAMIDOANILINE

Common Name

English

BENZAMIDE, M-AMINO-

Systematic Name

English

3-AMINOBENZAMIDE [HSDB]

Common Name

English

Code System Code Type Description

NSC

36962