3-AMINOBENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N2O
Molecular Weight	136.1512
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CC(N)=CC=C1

InChI

InChIKey=GSCPDZHWVNUUFI-UHFFFAOYSA-N

InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H8N2O
Molecular Weight	136.1512
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Poly (ADP-ribose) polymerase (Sus scrofa) 1 Target ID: Poly (ADP-ribose) polymerase (Sus scrofa) Sources: https://www.ncbi.nlm.nih.gov/pubmed/6248035	Inhibitor 8504		1.8 µM [Ki]

PubMed

Title	Date	PubMed
The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells.	2003-12	14612922
Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation.	2003-12	14514653
Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.	2003-11	12871856
Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat.	2003-10-31	14519512
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.	2003-10-22	14594650
Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells.	2003-10-15	14556861
Cellular events involved in butyric acid-induced T cell apoptosis.	2003-10-01	14500654
Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion.	2003-10	12964031
Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells.	2003-09	12957467
Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.	2003-08	14580150
The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells.	2003-08	12867996
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.	2003-08	12824290
The effect of PARS inhibition on ileal histopathology, apoptosis and lipid peroxidation in LPS-induced obstructive jaundice.	2003-08	12798666
Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.	2003-07-16	12866953
Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.	2003-07	12897815
Hsp70 attenuates hypoxia/reoxygenation-induced activation of poly(ADP-ribose) synthetase in the nucleus of adult rat cardiomyocytes.	2003-06	12870667
Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells.	2003-06	12753082
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.	2003-05-23	12782201
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.	2003-05	12686864
Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.	2003-05	12621128
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.	2003-03-12	12628304
Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.	2003-03-07	12506112
Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.	2003-03	12688429
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.	2003-03	12594058
gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells.	2003-02-17	12581860
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.	2003-02	12663936
Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.	2003-02	12576936
Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.	2003-01-15	12509801
Oxidant-induced cell death in renal epithelial cells: differential effects of inorganic and organic hydroperoxides.	2003-01	12710597
Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.	2003-01	12619896
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.	2003-01	12488552
Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.	2003	14580948
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.	2003	14520006
Bench-to-bedside review: Cytopathic hypoxia.	2002-12	12493070
Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.	2002-12	12490035
Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.	2002-12	12454457
The effect of H2O2 and tertiary butyl hydroperoxide upon a murine immortal lens epithelial cell line, alphaTN4-1.	2002-11	12457869
Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase.	2002-11	12412622
Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide, an inhibitior of parp enzyme.	2002-10-31	12379459
Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice.	2002-10-31	12379458
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.	2002-10	12237842
The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.	2002-09	12169758
Apoptosis inhibitors delay the cytopathic effect of bovine viral diarrhoea virus (BVDV).	2002-08	12241032
Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.	2002-08	12234774
The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.	2002-08	12220950
Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism.	2002-08	12154007
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.	2002-07-15	12140175
Poly(Adp-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm.	2002-07	12208123
tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator.	2002-07	12110167
Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury.	2002-07	12091461

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:48:59 GMT 2025` Edited by `admin` on `Mon Mar 31 18:48:59 GMT 2025`
Record UNII	8J365YF1YH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

3-AMINOBENZAMIDE

Systematic Name

English

NSC-36962

Preferred Name

English

(3-(AMINOCARBONYL)PHENYL)AMINE

Systematic Name

English

3-(AMINOCARBONYL)ANILINE

Systematic Name

English

BENZAMIDE, 3-AMINO-

Systematic Name

English

M-AMINOBENZAMIDE

Systematic Name

English

3-CARBOXAMIDOANILINE

Common Name

English

BENZAMIDE, M-AMINO-

Systematic Name

English

3-AMINOBENZAMIDE [HSDB]

Common Name

English

Code System Code Type Description

NSC

36962