Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H34O5 |
| Molecular Weight | 378.5024 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1C[C@@H](OC(C)=O)[C@H]2C(C)(C)CCC[C@]2(C)[C@@]1(O)CCC3=CC(=O)OC3
InChI
InChIKey=FBWWXAGANVJTLU-HEXLTJKYSA-N
InChI=1S/C22H34O5/c1-14-11-17(27-15(2)23)19-20(3,4)8-6-9-21(19,5)22(14,25)10-7-16-12-18(24)26-13-16/h12,14,17,19,25H,6-11,13H2,1-5H3/t14-,17-,19+,21+,22-/m1/s1
| Molecular Formula | C22H34O5 |
| Molecular Weight | 378.5024 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Vitexilactone is a new diterpene from Vitex cannabifolia, V. cannabinifolia, V. trifolia and Tinospora rumphii. This plant is known well as a treatment for HIV-AIDS and shown anti HIV-1 RT activities. Vitexilactone has shown anti HIV activities. Vitexilactone dramatically induced apoptosis both on tsFT210 and K562 cells at higher concentrations while at lower concentrations they inhibited the cell cycle progression of both tsFT210 and K562 cells at the G0/G1 phase.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor. | 2012 |
|
| Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. | 2007-04 |
|
| Ten new labdane-type diterpenes from the fruit of Vitex rotundifolia. | 2001-01 |
Patents
Sample Use Guides
Vitexilactone dramatically induced apoptosis of the tsFT210 cells at higher concentrations as detected as sub-G0/G1 peaks by flow cytometry after treatment of the cells at 100 ug/ml for 17 h. The
MIC of Vitexilactone for inducing apoptosis of tsFT210 cells was 25 ug/ml, respectively, while the concentration range for the G0/G1 phase inhibition of tsFT210 cell cycle was 50–6.25 ug/ml
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:24:30 GMT 2025
by
admin
on
Mon Mar 31 20:24:30 GMT 2025
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| Record UNII |
8HP9QLE96R
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| Record Status |
Validated (UNII)
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PARENT -> CONSTITUENT ALWAYS PRESENT |
