Diethylhomospermine is the polyamine analogue. It suppressed the activity of the major biosynthetic enzymes, ornithine decarboxylase and S-adenosylmethionine decarboxylase in human bladder cancer cell lines. Diethylhomospermine given as the subcutaneous injection is overall well tolerated at lower doses, but significant toxicities were observed at the 37.5mg/m2/day dose level. Maximal tolerated dose was established at 25 mg/m2/day but further investigation with this study drug is not recommended secondary to the potential for neurotoxicities and hepatic damage as a result of cumulative doses. Diethylhomospermine had been in phase II clinical trials for the treatment of AIDS-related chronic diarrhea. However, this research has been discontinued.