ANGOROSIDE C

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C36H48O19
Molecular Weight	784.7549
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(CCO[C@@H]2O[C@H](CO[C@@H]3OC[C@H](O)[C@H](O)[C@H]3O)[C@@H](OC(=O)\C=C\C4=CC=C(O)C(OC)=C4)[C@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H]2O)C=C1O

InChI

InChIKey=KLQXMRBGMLHBBQ-DQTDZZOCSA-N

InChI=1S/C36H48O19/c1-16-26(41)28(43)30(45)36(52-16)55-33-31(46)35(49-11-10-18-5-8-22(47-2)20(38)12-18)53-24(15-51-34-29(44)27(42)21(39)14-50-34)32(33)54-25(40)9-6-17-4-7-19(37)23(13-17)48-3/h4-9,12-13,16,21,24,26-39,41-46H,10-11,14-15H2,1-3H3/b9-6+/t16-,21-,24+,26-,27-,28+,29+,30+,31+,32+,33+,34-,35+,36-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C36H48O19
Molecular Weight	784.7549
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	14 / 14
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15010262 | https://www.ncbi.nlm.nih.gov/pubmed/15680992

Angoroside C is a potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and dGMP. Reveals some trypanocidal potential.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Trypanosoma brucei rhodesiense 3 Target ID: CHEMBL612348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15680992	Inhibitor 8297
Leishmania donovani 13 Target ID: CHEMBL367 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15680992	Inhibitor 8297
prostaglandin metabolic process 1 Target ID: GO:0006693 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15010262	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Leishmaniasis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15680992	Primary		Basic research	Unknown Approved Use Unknown
Inflammation 102 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15010262	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

The rats were orally administered with 7.5, 15 and 30 mg·kg(-1) of Angoroside C for 4 weeks.

Route of Administration: Oral

In Vitro Use Guide

At 0.1 mmol/L concentration, angoroside C and acteoside were able to repair the oxidized OH adducts dAMP and dGMP significantly.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:54:33 GMT 2023` Edited by `admin` on `Sat Dec 16 04:54:33 GMT 2023`
Record UNII	8G0I99W72T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANGOROSIDE C

Official Name

English

ANGOROSIDE C [INCI]

Common Name

English

GINSENGMAX

Brand Name

English

BETA.-D-GLUCOPYRANOSIDE, 2-(3-HYDROXY-4-METHOXYPHENYL)ETHYL O-.ALPHA.-L-ARABINOPYRANOSYL-(1-6)-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1-3))-, 4-((2E)-3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOATE)

Common Name

English

Code System Code Type Description

PUBCHEM

23757181

Created by admin on Sat Dec 16 04:54:34 GMT 2023 , Edited by admin on Sat Dec 16 04:54:34 GMT 2023

PRIMARY

CAS

115909-22-3

Created by admin on Sat Dec 16 04:54:34 GMT 2023 , Edited by admin on Sat Dec 16 04:54:34 GMT 2023

PRIMARY

EPA CompTox

DTXSID101021955

Created by admin on Sat Dec 16 04:54:34 GMT 2023 , Edited by admin on Sat Dec 16 04:54:34 GMT 2023

PRIMARY

FDA UNII

8G0I99W72T

Created by admin on Sat Dec 16 04:54:34 GMT 2023 , Edited by admin on Sat Dec 16 04:54:34 GMT 2023

PRIMARY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/15010262 | https://www.ncbi.nlm.nih.gov/pubmed/15680992

Approval Year

Targets

Conditions

Approved Use

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15010262 | https://www.ncbi.nlm.nih.gov/pubmed/15680992