Trabikibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:16:38 GMT 2025` Edited by `admin` on `Wed Apr 02 17:16:38 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8FL9JE4Q9H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Trabikibart

Common Name

English

Immunoglobulin G4 [225-proline], anti-(human ? common receptor) (human monoclonal CSL311 ?4-chain), disulfide with human monoclonal CSL311 ?-chain, dimer

Preferred Name

English

trabikibart [INN]

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens CSF2RB (colony stimulating factor 2 (granulocyte-macrophage) receptor beta chain, granulocyte-macrophage colony stimulating factor (GM CSF) receptor beta chain, IL3RB, IL5RB)], Homo sapiens monoclonal antibody

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199122

Created by admin on Wed Apr 02 17:16:38 GMT 2025 , Edited by admin on Wed Apr 02 17:16:38 GMT 2025

PRIMARY

FDA UNII

8FL9JE4Q9H

Created by admin on Wed Apr 02 17:16:38 GMT 2025 , Edited by admin on Wed Apr 02 17:16:38 GMT 2025

PRIMARY

CAS

2643974-98-3

Created by admin on Wed Apr 02 17:16:38 GMT 2025 , Edited by admin on Wed Apr 02 17:16:38 GMT 2025

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INN

12247

Created by admin on Wed Apr 02 17:16:38 GMT 2025 , Edited by admin on Wed Apr 02 17:16:38 GMT 2025

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SMS_ID

300000035836

Created by admin on Wed Apr 02 17:16:38 GMT 2025 , Edited by admin on Wed Apr 02 17:16:38 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_131	4_214
2_144	2_200
2_258	2_318
1_131	3_214
2_364	2_422
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_144	1_200
1_223	2_223
1_226	2_226
1_258	1_318
1_364	1_422

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_294
N	2_294

Related Record Type Details


					KIJ28K7WXF

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR HUMAN

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					SAE331OO65

CYTOKINE RECEPTOR COMMON SUBUNIT BETA

TARGET -> INHIBITOR

Qualification:

Kd

Amount:


					9O1TT75I7L

TARGET -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					8FL9JE4Q9H

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_444] [2_444]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL