PROTHROMBIN

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8FB1K07F16
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROTHROMBIN

Common Name

English

COAGULATION FACTOR II (HUMAN)

Preferred Name

English

COAGULATION FACTOR II HUMAN

Common Name

English

Factor ii (prothrombin) [WHO-DD]

Common Name

English

PROTHROMBIN [MI]

Common Name

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

305310

Agent Affecting Blood or Body Fluid

NCI_THESAURUS

C78311

Designated

FDA ORPHAN DRUG

225806

Established Pharmacologic Class

NDF-RT

N0000184168

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Code System

Code

Type

Description

MERCK INDEX

m9269

PRIMARY

FDA UNII

8FB1K07F16

PRIMARY

DAILYMED

8FB1K07F16

PRIMARY

SMS_ID

100000130058

PRIMARY

NCI_THESAURUS

C82273

PRIMARY

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Subunit 0

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From	To
1_17	1_22
1_47	1_60
1_65	1_143
1_86	1_126
1_170	1_248

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_78
N	1_100
N	1_373

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Related Record

Type

Details


					TN9BEX005G

BIVALIRUDIN

INHIBITOR -> TARGET


					W1DT53SAN0

PF-05230907

TARGET -> SUBSTRATE


					I0VM4M70GC

DABIGATRAN

INHIBITOR -> TARGET

Amount:

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Related Record

Type

Details


					8FB1K07F16

PROTHROMBIN

ACTIVE MOIETY

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_6] [1_7] [1_14] [1_16] [1_19] [1_20] [1_25] [1_26] [1_29] [1_32]	SITE_SPECIFIC			.GAMMA.-CARBOXYGLUTAMIC ACID	16FQV4RZKL

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C2868H4413O899N815S32
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 64000 Da (average)

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