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Details

Stereochemistry ABSOLUTE
Molecular Formula C33H40N2O9
Molecular Weight 608.6787
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHOSERPIDINE

SMILES

[H][C@]12C[C@@H](OC(=O)C3=CC(OC)=C(OC)C(OC)=C3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]4([H])N(CCC5=C4NC6=C5C=C(OC)C=C6)C2

InChI

InChIKey=ULBNWNUHGJLQHO-VKMIBBQISA-N
InChI=1S/C33H40N2O9/c1-38-19-7-8-23-22(14-19)20-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)21(18)15-24(35)29(20)34-23/h7-8,11-12,14,18,21,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,21+,24-,27-,28+,31+/m1/s1

HIDE SMILES / InChI
Molecular Formula C33H40N2O9
Molecular Weight 608.6787
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Methoserpidine is a synthetic isomer of reserpine, used in the 1960s as an antihypertensive drug. Initially, it was reported to be free from CNS side effects of reserpine (mild suppression of alertness, and mental depression). However, later clinical experience has shown that in a significant proportion of patients administration of the drug lead to episodes of depression.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Methoserpidine, a non-depressant isomer of reserpine.
1961 Aug 12
DEPRESSION AFTER METHOSERPIDINE.
1965 Sep 4
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:11:05 GMT 2023
Edited
by admin
on Sat Dec 16 17:11:05 GMT 2023
Record UNII
8F8C1JQH53
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHOSERPIDINE
INN   MART.   WHO-DD  
INN  
Official Name English
methoserpidine [INN]
Common Name English
R-694
Code English
RESERTENE
Brand Name English
(-)-10-METHOXYDESERPIDINE
Common Name English
3.BETA.,20.ALPHA.-YOHIMBAN-16.BETA.-CARBOXYLIC ACID, 18.BETA.-HYDROXY-10,17.ALPHA.-DIMETHOXY-, METHYL ESTER, 3,4,5-TRIMETHOXYBENZOATE (ESTER)
Common Name English
DESERPIDINE 10-METHOXYDESERPIDINE
MI  
Common Name English
YOHIMBAN-16-CARBOXYLIC ACID, 10,17-DIMETHOXY-18-((3,4,5-TRIMETHOXYBENZOYL)OXY)-, METHYL ESTER, (3.BETA.,16.BETA.,17.ALPHA.,18.BETA.,20.ALPHA.)-
Common Name English
R 694
Code English
DECASERPIN
Common Name English
DESERPIDINE, 10-METHOXY-
Common Name English
10-MD
Common Name English
DECASERPINE
Common Name English
DECASERPIL
Common Name English
DECASERPYL
Common Name English
NSC-169423
Code English
NEOSERPIN
Brand Name English
DECOSERPYL
Common Name English
10-METHOXYDESERPIDINE
Common Name English
MINORAN
Brand Name English
DEASERPYL
Common Name English
Methoserpidine [WHO-DD]
Common Name English
DESERPIDINE 10-METHOXYDESERPIDINE [MI]
Common Name English
TENSERPINA
Common Name English
METHOSERPIDINE [MART.]
Common Name English
Classification Tree Code System Code
WHO-VATC QC02LA04
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
WHO-ATC C02LA04
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
WHO-ATC C02AA06
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
WHO-VATC QC02AA06
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
Code System Code Type Description
FDA UNII
8F8C1JQH53
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105867
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
NCI_THESAURUS
C175134
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
EVMPD
SUB08855MIG
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
SMS_ID
100000081435
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
MERCK INDEX
m4189
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY Merck Index
DRUG CENTRAL
1750
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
RXCUI
235829
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
METHOSERPIDINE
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
PUBCHEM
71798
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
DRUG BANK
DB13631
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
ECHA (EC/EINECS)
212-733-5
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
INN
1081
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
CAS
865-04-3
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID001024699
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
NSC
169423
Created by admin on Sat Dec 16 17:11:05 GMT 2023 , Edited by admin on Sat Dec 16 17:11:05 GMT 2023
PRIMARY
Related Record Type Details
Structure of METHOSERPIDINE
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