LEUKOTRIENE E4

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H37NO5S
Molecular Weight	439.609
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	4
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O

InChI

InChIKey=OTZRAYGBFWZKMX-FRFVZSDQSA-N

InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H37NO5S
Molecular Weight	439.609
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	4
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.	1993 Dec	8303624
Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.	1993 Feb 15	8384568
A controlled trial of the effect of the 5-lipoxygenase inhibitor, zileuton, on lung inflammation produced by segmental antigen challenge in human beings.	1996 Feb	8621850
Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma.	1998 Apr	9547367
Pharmacology of leukotriene receptor antagonists.	1998 Jun	9620942
Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers.	1999 Jan 22	9890956
Characterization of the human cysteinyl leukotriene CysLT1 receptor.	1999 Jun 24	10391245
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.	1999 Sep	10462554
Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics.	2000 Apr	10764316
The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor.	2000 Aug 2	10913337
Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.	2000 Dec	11093801
Characterization of the human cysteinyl leukotriene 2 receptor.	2000 Sep 29	10851239
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.	2001 Nov 1	11705452
Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients.	2002 Dec	12464047
Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma.	2002 Feb 1	11834255
[Study on relationship between leukotrienes and exercise-induced asthma].	2002 Jan 10	11953129
Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13.	2003 Apr	12654629
The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle.	2003 Aug	12853847
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.	2003 Oct	12794006
Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma.	2004 Apr	15100686
Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma.	2005 Feb	15696079
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.	2008	18974869
Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays.	2011 Feb	21078884
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.	2013 Apr 19	23504326
Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury.	2015 Feb	25432964

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:54:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:54:24 GMT 2023`
Record UNII	8EYT8ATL7G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEUKOTRIENE E4

Common Name

English

(5S,6R,7E,9E,11Z,14Z)-6-(2-AMINO-2-CARBOXYETHYL)SULFANYL-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC ACID

Systematic Name

English

LEUKOTRIENE E

Common Name

English

LEUKOTRIENE E4 [MI]

Common Name

English

LTE4

Common Name

English

LTE-4

Common Name

English

Classification Tree Code System Code

LOINC

33344-3