Dibenzosuberone

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H12O
Molecular Weight	208.2552
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=BMVWCPGVLSILMU-UHFFFAOYSA-N

InChI=1S/C15H12O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-8H,9-10H2

HIDE SMILES / InChI

Molecular Formula	C15H12O
Molecular Weight	208.2552
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22676210 | https://www.ncbi.nlm.nih.gov/pubmed/18007539 | https://www.google.com/patents/EP2152258A1

Dibenzosuberone is used for the organic synthesis. Dibenzosuberone derivatives are potent inhibitors of p38 mitogen-activated protein kinase. They may foster a new generation of anti-inflammatory drugs. Dibenzosuberone derivatives are potential tricyclic antidepressants and anti-tumor agents.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.	2013-01-10	23270382
Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.	2012-06-28	22676210
Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test.	2008-02-15	17920179
Sensitive extractive spectrophotometric methods for the determination of nortriptyline hydrochloride in pharmaceutical formulations.	2007-12	18057736
Synthesis of novel, potentially biologically active dibenzosuberone derivatives.	2005-12-31	18007539
2H NMR and X-ray diffraction studies of methyl rotation in crystals of ortho-methyldibenzocycloalkanones.	2005-07	16026685

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:07:51 GMT 2025` Edited by `admin` on `Mon Mar 31 18:07:51 GMT 2025`
Record UNII	8ETK71TH0H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMITRIPTYLINE RELATED COMPOUND A

Preferred Name

English

Dibenzosuberone

Common Name

English

NORTRIPTYLINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

DIBENZOCYCLOHEPTENONE

Systematic Name

English

10,11-DIHYDRO-5H-DIBENZO(A,D)(7)ANNULEN-5-ONE

Common Name

English

5H-DIBENZO(A,D)CYCLOHEPTEN-5-ONE, 10,11-DIHYDRO-

Systematic Name

English

2,3:6,7-DIBENZOSUBERONE

Common Name

English

10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTAN-5-ONE

Common Name

English

NSC-49727

Code

English

AMITRIPTYLINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

AMITRIPTYLINE RELATED COMPOUND A [USP-RS]

Common Name

English

DIBENZO(A,D)CYCLOHEPTA(1,4)DIEN-5-ONE

Common Name

English

DIBENZOSUBERAN-5-ONE

Common Name

English

10,11-DIHYDRODIBENZO(A,D)CYCLOHEPTEN-5-ONE

Systematic Name

English

DIBENZO(A,D)CYCLOHEPTADIEN-5-ONE

Common Name

English

Code System Code Type Description

PUBCHEM

14589