NEOCUPROINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H12N2
Molecular Weight	208.2585
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C2C=CC3=CC=C(C)N=C3C2=N1

InChI

InChIKey=IYRGXJIJGHOCFS-UHFFFAOYSA-N

InChI=1S/C14H12N2/c1-9-3-5-11-7-8-12-6-4-10(2)16-14(12)13(11)15-9/h3-8H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C14H12N2
Molecular Weight	208.2585
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23604539\| https://www.ncbi.nlm.nih.gov/pubmed/12633744	Inhibitor 8504
C-C chemokine receptor type 5 20 Target ID: CHEMBL274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Activator 1447	67.0 µM [EC50]
C-C chemokine receptor type 1 11 Target ID: CHEMBL2413 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Activator 1447	1.6 µM [EC50]

PubMed

Title	Date	PubMed
Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.	2011-02-01	21167140
Magneto-structural studies on heterobimetallic malonate-bridged M(II)Re(IV) complexes (M = Mn, Co, Ni and Cu).	2010-12-21	20978677
Bis(2,9-dimethyl-1,10-phenanthrolin-1-ium) hydrogen (S,S)-tartrate nona-hydrate.	2010-12-11	21522796
Aqua-(2,9-dimethyl-1,10-phenanthroline-κN,N')(formato-κO,O')(formato-κO)cobalt(II) monohydrate.	2010-12-04	21522561
Oxygen gas sensing by luminescence quenching in crystals of Cu(xantphos)(phen)+ complexes.	2010-10-13	20853869
DNA binding, cytotoxicity, and apoptotic-inducing activity of ruthenium(II) polypyridyl complex.	2010-07	20705582
DNA binding and gel electrophoresis studies of a copper (II) complex containing mixed aliphatic and aromatic dinitrogen ligands.	2010-06	20380572
Tritopic phenanthroline and pyridine tail-tied aza-scorpiands.	2010-05-21	20448894
Stability of disubstituted copper complexes in the gas phase analyzed by electrospray ionization mass spectrometry.	2010-05-15	20391604
Bis[bis-(4,4'-dimethyl-2,2'-bipyridine)(10,11,12,13-tetra-hydro-dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(II)] tetra-kis(perchlorate) acetonitrile disolvate monohydrate.	2010-04-21	21579038
Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity.	2010-04-15	20045017
Bis(2,9-dimethyl-1,10-phenanthroline-κN,N')(10,11,12,13-tetra-hydro-dipyrido[3,2-a:2',3'-c]phenazine-κN,N)ruthenium(II) bis-(perchlorate) dihydrate.	2010-01-30	21579673
2,9-Bis(trichloro-meth-yl)-1,10-phenanthroline.	2010-01-23	21579839
Syntheses, structures and spectroscopy of uni- and bi-dentate nitrogen base complexes of silver(I) trifluoromethanesulfonate.	2010-01-21	20066236
Bis(2,2'-bipyridyl-κN,N')bis-(2-hydroxy-benzoato)-κO;κO,O-cadmium(II) methanol solvate.	2010-01-16	21579632
Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of the complexes [M(dmphen)(CO3)].H2O [M=Pt(II), Pd(II)].	2010-01	19913954
Dichlorido(2,9-dimethyl-1,10-phenanthroline)manganese(II) hemihydrate.	2009-11-21	21578670
(6,6'-Dimethyl-2,2'-bipyridine-κN,N')diiodidozinc(II).	2009-10-28	21578171
Dibromido(6,6'-dimethyl-2,2'-bipyridine-κN,N')zinc(II).	2009-10-07	21578074
Dichlorido(6,6'-dimethyl-2,2'-bipyridine-κN,N')zinc(II).	2009-09-26	21577766
Dichlorido(2,9-dimethyl-1,10-phenanthroline-κN,N')copper(II).	2009-09-05	21577696
Equilibrium and ab initio computational studies on the adduct formation of 1,3-diketonato-lithium(I), -sodium(I) and -potassium(I) with 1,10-phenanthroline and its 2,9-dimethyl derivatives.	2009-06-15	19362187
Dichloridobis(phenanthridine-κN)zinc(II).	2009-06-06	21582680
Capturing and analyzing the excited-state structure of a Cu(I) phenanthroline complex by time-resolved diffraction and theoretical calculations.	2009-05-13	19378949
Synthesis, crystal structure, cytotoxic activities and DNA-binding properties of new binuclear copper(II) complexes bridged by N,N'-bis(N-hydroxyethylaminoethyl)oxamide.	2009-05	19324417
Bis(phenanthridinium) hexa-chloridoplatinate(IV) dimethyl sulfoxide disolvate.	2009-01-28	21581825
Aqua-(2,9-dimethyl-1,10-phenanthroline-κN,N')bis-(2-hydroxy-benzoato-κO)manganese(II) 2,9-dimethyl-1,10-phenanthroline hemisolvate.	2009-01-14	21581794
Diaqua-(2,9-dimethyl-1,10-phenanthroline-κN,N')(4-hydroxy-benzoato-κO,O')cobalt(II) nitrate dihydrate.	2008-11-22	21581191
(2,9-Dimethyl-1,10-phenanthroline-κN,N')bis-(2-hydroxy-benzoato-κO)copper(II).	2008-11-13	21581143
(2,9-Dimethyl-1,10-phenanthroline-κN,N')(4-hydroxy-benzoato-κO,O')(nitrato-κO)copper(II).	2008-10-31	21580912
New chemistry of olefin complexes of platinum(II) unravelled by basic conditions: synthesis and properties of elusive cationic species.	2008-10-21	18827938
A new approach for the detection of ethylene using silica-supported palladium complexes.	2008-10-06	18729446
(4,7-Diphenyl-1,10-phenanthroline-κN,N')diiodidomercury(II).	2008-09-27	21201072
Theoretical characterization of a typical hole/exciton-blocking material bathocuproine and its analogues.	2008-09-25	18729426
Bis(2,4,6-trimethyl-pyridinium) hexa-chloridoplatinate(IV).	2008-09-13	21201020
Dichlorido(6-methyl-2,2'-bipyridine-κN,N')zinc(II).	2008-09-13	21201019
(4,4'-Dimethyl-2,2'-bipyridine-κN,N')diiodidomercury(II).	2008-09-13	21201014
An unusual two-dimensional hydrogen-bonding network in bis(2,9-dimethyl-1,10-phenanthrolin-1-ium) peroxodisulfate dihydrate.	2008-09	18758017
Bis(2,6-dimethyl-pyridinium) hexa-chlorido-platinate(IV).	2008-08-09	21201599
A second polymorph of aqua-(2,9-di-methyl-1,10-phenanthroline-κN,N')bis-(formato-κO)copper(II).	2008-07-26	21203045
Three-dimensional local structure of photoexcited Cu diimine complex refined by quantitative XANES analysis.	2008-06-19	18505241
(2,9-Dimethyl-1,10-phenanthroline-κN,N')bis-(2-hydroxy-benzoato)-κO;κO,O'-cobalt(II).	2008-04-30	21202260
Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.	2008-03	18056745
Bis(benzoato-κO,O')(2,9-dimethyl-1,10-phenanthroline-κN,N')cobalt(II).	2008-01-09	21201295
Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.	2008	18346929
Synchronized fluxional motion and cyclometalation of ligands in platinum(II) complexes.	2007-12-10	17999491
Synthesis, crystal structure and magnetic properties of novel heterobimetallic malonate-bridged MIIReIV complexes (M = Mn, Fe, Co and Ni).	2007-12-07	18271487
RNA cleavage by 2,9-diamino-1,10-phenanthroline PNA conjugates.	2007	18066810
Utilization of activating and masking effects by ligands for highly selective catalytic spectrophotometric determination of copper and iron in natural waters.	2003-08-29	18969144
Investigation of the reaction of copper(I) with 2,9-dimethyl-1,10-phenanthroline at trace level by thermal lensing.	2002-07-03	18968686

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:21:10 GMT 2025` Edited by `admin` on `Mon Mar 31 21:21:10 GMT 2025`
Record UNII	8E7D2SH3BV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-4280

Preferred Name

English

NEOCUPROINE

Common Name

English

NEOCUPROINE [MI]

Common Name

English

2,9-NEOCUPROINE

Common Name

English

VUF-7738

Code

English

2,9-DIMETHYLPHENANTHROLINE

Systematic Name

English

2,9-DIMETHYL-O-PHENANTHROLINE

Common Name

English

2,9-DIMETHYL-1,10-PHENANTHROLINE

Systematic Name

English

DMPHEN

Common Name

English

NEOCUPROIN

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID5060065