Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C7H14NO2 |
| Molecular Weight | 144.1916 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C[N+]1(C)CCC[C@H]1C(O)=O
InChI
InChIKey=CMUNUTVVOOHQPW-LURJTMIESA-O
InChI=1S/C7H13NO2/c1-8(2)5-3-4-6(8)7(9)10/h6H,3-5H2,1-2H3/p+1/t6-/m0/s1
| Molecular Formula | C7H13NO2 |
| Molecular Weight | 143.1836 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. Stachydrine is an anti-metastatic agent. Stachydrine hydrochloride induces apoptosis in MCF-7 and T47D cells and exerts inhibitory effects on proliferation by concurrently suppressing Akt and ERK survival signals, suggesting its potential efficiency in treatment of breast cancer. Stachydrine (Sta) has also been reported to possess numerous cardioprotective effects. It ameliorated pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1287627 |
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Target ID: map04064 |
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Target ID: map04064 |
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Target ID: CHEMBL1287627 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Palliative | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Osmoregulation in Klebsiella pneumoniae: enhancement of anaerobic growth and nitrogen fixation under stress by proline betaine, gamma-butyrobetaine, and other related compounds. | 1984 Mar |
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| Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney. | 1987 Mar |
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| Glycine betaine and proline betaine in human blood and urine. | 1994 Aug 18 |
Patents
Sample Use Guides
Stachydrine was administered intragastrically (8 mg/kg) to Wistar rats after Transverse aortic constriction(TAC).
Route of Administration:
Intragastric
The effect of Stachydrine hydrochloride on the proliferation of MCF-7 and T47D cells when incubated with different concentrations of Stachydrine hydrochloride (0 uM, 50 uM, 200 uM, 500 uM and 1000 uM) was evaluated using the CCK-8 assay. The results showed that treatment with Stachydrine hydrochloride noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner. IC50 of Stachydrine hydrochloride for MCF-7 and T47D is about 500 uM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:24:33 GMT 2023
by
admin
on
Sat Dec 16 09:24:33 GMT 2023
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| Record UNII |
8DQ7SQ4VA9
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| Record Status |
Validated (UNII)
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| Record Version |
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