Methyl phenothiazin-2-yl ketone

CC(=O)C1=CC=C2SC3=C(NC2=C1)C=CC=C3

InChIKey=JWGBOHJGWOPYCL-UHFFFAOYSA-N

InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
NADPH oxidase 1 6 Target ID: CHEMBL1287628 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20715845	Inhibitor 8504		0.25 µM [IC50]

PubMed

Title	Date	PubMed
Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes.	2013	23940720
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.	2010-10-15	20715845
Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA.	2006-09	16984889
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005-06	15962942

Patents

Substance Class	Chemical Created by `admin` on `Tue Apr 01 19:11:17 GMT 2025` Edited by `admin` on `Tue Apr 01 19:11:17 GMT 2025`
Record UNII	8DEE7H3XAB
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NSC-169669

Preferred Name

English

Methyl phenothiazin-2-yl ketone

Systematic Name

English

Ketone, methyl phenothiazin-2-yl

Common Name

English

NSC-57951

Code

English

Ethanone, 1-(10H-phenothiazin-2-yl)-

Systematic Name

English

1-(10H-Phenothiazin-2-yl)ethanone

Systematic Name

English

Code System Code Type Description

CAS

6631-94-3