HYPOXIA-INDUCIBLE FACTOR 1-ALPHA

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:13:30 GMT 2025` Edited by `admin` on `Tue Apr 01 20:13:30 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	8CMA3U7ORZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYPOXIA-INDUCIBLE FACTOR 1-ALPHA

Common Name

English

ARNT-INTERACTING PROTEIN

Preferred Name

English

HIF1-ALPHA

Common Name

English

HIF1A

Common Name

English

BASIC-HELIX-LOOP-HELIX-PAS PROTEIN MOP1

Common Name

English

PAS DOMAIN-CONTAINING PROTEIN 8

Common Name

English

BHLHE78

Common Name

English

MEMBER OF PAS PROTEIN 1

Common Name

English

PASD8

Common Name

English

MOP1

Common Name

English

CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 78

Common Name

English

Code System Code Type Description

FDA UNII

8CMA3U7ORZ

Created by admin on Tue Apr 01 20:13:30 GMT 2025 , Edited by admin on Tue Apr 01 20:13:30 GMT 2025

PRIMARY

UNIPROT

Q16665

Created by admin on Tue Apr 01 20:13:30 GMT 2025 , Edited by admin on Tue Apr 01 20:13:30 GMT 2025

PRIMARY

PHAROS

Q16665

Created by admin on Tue Apr 01 20:13:30 GMT 2025 , Edited by admin on Tue Apr 01 20:13:30 GMT 2025

PRIMARY

Related Record Type Details


					2KL3NSB2NP

IZILENDUSTAT

STABILIZER->TARGET

Amount:


					5XQ7LE6DZG

BAY-87-2243

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_247] [1_551] [1_576] [1_589] [1_657]	S	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_555]	T	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_532] [1_709]	K	N6-ACETYLLYSINE	470AD5VY1X
AMINO ACID SUBSTITUTION	[1_800]	C	S-NITROSOCYSTEINE	926P2322P4
AMINO ACID SUBSTITUTION	[1_402] [1_564]	P	HYDROXYPROLINE	RMB44WO89X
AMINO ACID SUBSTITUTION	[1_803]	N	3-HYDROXYASPARAGINE, (3S)-	9J17BCS69U

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL