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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 03:29:15 GMT 2025
Edited
by admin
on Wed Apr 02 03:29:15 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
8B1J60R28A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Firastotug
INN  
Official Name English
ADG-116
Preferred Name English
immunoglobulin G1- kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], monoclonal antibody (Firastotug)
Common Name English
firastotug [INN]
Common Name English
gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV3-7*01 (77.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [9.7.9] (26-34.52-58.97-105)) (1-116) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-3
Common Name English
ADG116
Code English
ADG 116 [WHO-DD]
Common Name English
Immunoglobulin G1, anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal ADG116 ?1-chain), disulfide with human monoclonal ADG116 ?-chain, dimer
Common Name English
Code System Code Type Description
CAS
2750031-14-0
Created by admin on Wed Apr 02 03:29:15 GMT 2025 , Edited by admin on Wed Apr 02 03:29:15 GMT 2025
PRIMARY
FDA UNII
8B1J60R28A
Created by admin on Wed Apr 02 03:29:15 GMT 2025 , Edited by admin on Wed Apr 02 03:29:15 GMT 2025
PRIMARY
SMS_ID
300000050030
Created by admin on Wed Apr 02 03:29:15 GMT 2025 , Edited by admin on Wed Apr 02 03:29:15 GMT 2025
PRIMARY
INN
12569
Created by admin on Wed Apr 02 03:29:15 GMT 2025 , Edited by admin on Wed Apr 02 03:29:15 GMT 2025
PRIMARY
NCI_THESAURUS
C166139
Created by admin on Wed Apr 02 03:29:15 GMT 2025 , Edited by admin on Wed Apr 02 03:29:15 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_143 2_199
2_219 4_215
2_260 2_320
1_143 1_199
2_366 2_424
3_23 3_89
3_135 3_195
4_23 4_89
4_135 4_195
1_219 3_215
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
Firastotug
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_446] [2_446] C-TERMINUS K LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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