1-(2-Furoyl)piperazine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H12N2O2
Molecular Weight	180.2038
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N1CCNCC1)C2=CC=CO2

InChI

InChIKey=SADPINFEWFPMEA-UHFFFAOYSA-N

InChI=1S/C9H12N2O2/c12-9(8-2-1-7-13-8)11-5-3-10-4-6-11/h1-2,7,10H,3-6H2

HIDE SMILES / InChI

Molecular Formula	C9H12N2O2
Molecular Weight	180.2038
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22424148 | https://www.ncbi.nlm.nih.gov/pubmed/833813 | https://www.ncbi.nlm.nih.gov/pubmed/11178831 | Beringer, P., Troy, D.B. (2006) Remington: The Science and Practice of Pharmacy, page 1400, retrieved from: https://books.google.ru/books?id=NFGSSSbaWjwC

1-(2-Furoyl)piperazine is the Terazosin impurity (Impurity L). It is used in the synthesis of Piperazine. It was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.	2012-04-12	22424148
Traceless solid-phase synthesis of 2,4-diaminoquinazolines.	2001-02-22	11178831
Synthesis and identification of the major metabolites of prazosin formed in dog and rat.	1977-01	833813

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:11:41 GMT 2025` Edited by `admin` on `Mon Mar 31 22:11:41 GMT 2025`
Record UNII	8AUX72LL1P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(2-Furoyl)piperazine

Systematic Name

English

(FURAN-2-YL)(PIPERAZIN-1-YL)METHANONE

Preferred Name

English

PRAZOSIN RELATED COMPOUND D [USP-RS]

Common Name

English

1-(FURAN-2-YLCARBONYL)PIPERAZINE

Systematic Name

English

N-(FURAN-2-OYL)PIPERAZINE

Systematic Name

English

PRAZOSIN HYDROCHLORIDE IMPURITY D [EP IMPURITY]

Common Name

English

N-(2-FUROYL)PIPERAZINE

Systematic Name

English

1-PENTANONMETHANONE, 2-FURANYL-1-PIPERAZINYL-

Systematic Name

English

TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY L [EP IMPURITY]

Common Name

English

Code System Code Type Description

PUBCHEM

550206