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Details

Stereochemistry ACHIRAL
Molecular Formula C3Cl2N3O3.K
Molecular Weight 236.055
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TROCLOSENE POTASSIUM

SMILES

[K+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O

InChI

InChIKey=IFIDXBCRSWOUSB-UHFFFAOYSA-M
InChI=1S/C3HCl2N3O3.K/c4-7-1(9)6-2(10)8(5)3(7)11;/h(H,6,9,10);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C3HCl2N3O3
Molecular Weight 197.964
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Overview

Overview

OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Improvements to water purification and sanitation infrastructure may reduce the diarrheal burden in a marginalized and flood prone population in remote Nicaragua.
2010-12-08
Root canal irrigants.
2010-10
Field assessment of a novel household-based water filtration device: a randomised, placebo-controlled trial in the Democratic Republic of Congo.
2010-09-10
1,1'-Azobis-1,2,3-triazole: a high-nitrogen compound with stable N8 structure and photochromism.
2010-09-08
Disinfection by-product formation and mitigation strategies in point-of-use chlorination with sodium dichloroisocyanurate in Tanzania.
2010-07
Jasmonic acid and ethylene modulate local responses to wounding and simulated herbivory in Nicotiana attenuata leaves.
2010-06
Disinfection efficacy of sodium dichloroisocyanurate (NADCC) against common food-borne intestinal protozoa.
2010-04
[Specific antisepsis and environmental disinfection in preventing "Clostridium difficile associated diarrhea"].
2010-02-23
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.
2010-02-03
Sodium dichloroisocyanurate tablets for routine treatment of household drinking water in periurban Ghana: a randomized controlled trial.
2010-01
Collection of indonaphthol blue on a membrane filter for the spectrophotometric determination of ammonia with 1-naphthol and dichloroisocyanurate.
2010
A comparative study assaying commonly used sanitizers for antimicrobial activity against indicator bacteria and a Salmonella Typhimurium strain on fresh produce.
2009-11
Use of sodium dichloroisocyanurate for floor disinfection.
2009-07
Disinfection of irreversible hydrocolloid impression material with chlorinated compounds.
2009-06
Effects of pH and oil-in-water emulsions on growth and physicochemical cell surface properties of Listeria monocytogenes: Impact on tolerance to the bactericidal activity of disinfectants.
2009-03-31
Tonometer disinfection practice in the United Kingdom: a national survey.
2008-08
UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol.e.
2008-05-12
Sporicidal activity of two disinfectants against Clostridium difficile spores.
2008-04-17
Advantages of sodium hypochlorite or sodium dichloroisocyanurate disinfection for teats and bottles in newborn infants' feeding.
2008-02-26
Virucidal agents in the eve of manorapid synergy.
2007-09-13
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains.
2007-08
Analytical method for the quantitative determination of cyanuric acid as the degradation product of sodium dichloroisocyanurate in urine by liquid chromatography mass spectrometry.
2007-06-15
Comparative sporicidal effects of disinfectants after release of a biological agent.
2007-06
Household water treatment using sodium dichloroisocyanurate (NaDCC) tablets: a randomized, controlled trial to assess microbiological effectiveness in Bangladesh.
2007-01
Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.
2006-05
Sodium dichloroisocyanurate (NaDCC) tablets as an alternative to sodium hypochlorite for the routine treatment of drinking water at the household level.
2006-03
[Comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].
2006-01
[Study on the resistance of Escherichia coli O157:H7 to disinfectants in relationship with its plasmid pO157 and chromosome DNA].
2005-11
Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds.
2005-04
Flow-injection potentiometric determination of triiodide by plasticized poly(vinyl chloride) membrane electrodes and its application to the determination of chlorine-containing disinfectants.
2005-03-15
The effect of a range of disinfectants on the dimensional accuracy of some impression materials.
2004-12
Soft tissue dissolution capacity of currently used and potential endodontic irrigants.
2004-11
The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips.
2004-09
Efficacy of three surface disinfectants for dental radiographic films and gloves.
2004-07
The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces.
2004-06
Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.
2004-06
[Bioactive effectiveness of selected disinfective agents on Gram-negative bacilli isolated from hospital environment].
2004
Resistance of spheroplasts and whole cells of Pseudomonas aeruginosa to bactericidal activity of various biocides: evidence of the membrane implication.
2004
Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes.
2003-10-17
Effects of different disinfection treatments on the natural microbiota of lettuce.
2003-09
Determination of ammonia in beers by pervaporation flow injection analysis and spectrophotometric detection.
2003-08-29
The effect of potassium permanganate and sodium dichloroisocyanurate on metacercariae of Fasciola gigantica.
2003-04
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.
2003-02
Sanichlor-induced atopic dermatitis and asthma in ophthalmologists.
2003-01
Flow injection chemiluminescence determination of hydrazine by oxidation with chlorinated isocyanurates.
2002-10-16
Germicidal activities of representatives of five different teat dip classes against three bovine mycoplasma species using a modified excised teat model.
2002-08
Preventing infection from reusable medical equipment: a systematic review.
2002-03-27
Reduction of mastitis caused by experimental challenge with Staphylococcus aureus and Streptococcus agalactiae by use of a quaternary ammonium and halogen-mixture teat dip.
2002-01
[Sodium dichloroisocyanurate: a major disinfectant for drinking water].
2002
Life threatening airway obstruction in a newborn following ingestion of sterilising tablet.
2001-11
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.
Substance Class Chemical
Created
by admin
on Wed Apr 02 09:42:28 GMT 2025
Edited
by admin
on Wed Apr 02 09:42:28 GMT 2025
Record UNII
8A85D111P0
Record Status Validated (UNII)
Record Version
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Name Type Language
POTASSIUM TROCLOSENE
INCI  
INCI  
Preferred Name English
TROCLOSENE POTASSIUM
HSDB   INN   MART.   MI   USAN  
USAN   INN  
Official Name English
POTASSIUM DICHLOROISOCYANURATE
Common Name English
POTASSIUM DICHLOROCYANURATE
Common Name English
1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-, POTASSIUM SALT
Common Name English
TROCLOSENE POTASSIUM [MART.]
Common Name English
troclosene potassium [INN]
Common Name English
1,3-DICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)TRIONE POTASSIUM SALT
Common Name English
TROCLOSENE POTASSIUM [USAN]
Common Name English
NSC-251767
Code English
TROCLOSENE POTASSIUM [MI]
Common Name English
TROCLOSENE POTASSIUM [HSDB]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 81403
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
NCI_THESAURUS C28394
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
Code System Code Type Description
PUBCHEM
517106
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
ChEMBL
CHEMBL2111065
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
HSDB
5871
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
EVMPD
SUB11330MIG
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
ECHA (EC/EINECS)
218-828-8
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
NSC
251767
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
MERCK INDEX
m11216
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY Merck Index
CAS
2244-21-5
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
INN
1772
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
NCI_THESAURUS
C152756
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
EPA CompTox
DTXSID5026178
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
SMS_ID
100000076973
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
FDA UNII
8A85D111P0
Created by admin on Wed Apr 02 09:42:28 GMT 2025 , Edited by admin on Wed Apr 02 09:42:28 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY