TROCLOSENE POTASSIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3Cl2N3O3.K
Molecular Weight	236.055
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O

InChI

InChIKey=IFIDXBCRSWOUSB-UHFFFAOYSA-M

InChI=1S/C3HCl2N3O3.K/c4-7-1(9)6-2(10)8(5)3(7)11;/h(H,6,9,10);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/61/NaDCC.pdf
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diarrhea 35 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20064989 https://www.ncbi.nlm.nih.gov/pubmed/23976883	Preventing		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.	2003 Feb	12589508
Sanichlor-induced atopic dermatitis and asthma in ophthalmologists.	2003 Jan	12579187
The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips.	2004 Sep	15369476
Comparative sporicidal effects of disinfectants after release of a biological agent.	2007 Jun	17615843
Analytical method for the quantitative determination of cyanuric acid as the degradation product of sodium dichloroisocyanurate in urine by liquid chromatography mass spectrometry.	2007 Jun 15	17409034
Tonometer disinfection practice in the United Kingdom: a national survey.	2008 Aug	17464301
Sporicidal activity of two disinfectants against Clostridium difficile spores.	2008 Mar 13-26	18414294
Advantages of sodium hypochlorite or sodium dichloroisocyanurate disinfection for teats and bottles in newborn infants' feeding.	2008 Mar-Apr	18294178
A comparative study assaying commonly used sanitizers for antimicrobial activity against indicator bacteria and a Salmonella Typhimurium strain on fresh produce.	2009 Nov	19903410
Collection of indonaphthol blue on a membrane filter for the spectrophotometric determination of ammonia with 1-naphthol and dichloroisocyanurate.	2010	20631439
Improvements to water purification and sanitation infrastructure may reduce the diarrheal burden in a marginalized and flood prone population in remote Nicaragua.	2010 Dec 8	21143865
Sodium dichloroisocyanurate tablets for routine treatment of household drinking water in periurban Ghana: a randomized controlled trial.	2010 Jan	20064989
Root canal irrigants.	2010 Oct	21217955
Field assessment of a novel household-based water filtration device: a randomised, placebo-controlled trial in the Democratic Republic of Congo.	2010 Sep 10	20856584
1,1'-Azobis-1,2,3-triazole: a high-nitrogen compound with stable N8 structure and photochromism.	2010 Sep 8	20715773

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:52:23 UTC 2023` Edited by `admin` on `Sat Dec 16 17:52:23 UTC 2023`
Record UNII	8A85D111P0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TROCLOSENE POTASSIUM

Official Name

English

POTASSIUM DICHLOROISOCYANURATE

Common Name

English

POTASSIUM DICHLOROCYANURATE

Common Name

English

1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-, POTASSIUM SALT

Common Name

English

TROCLOSENE POTASSIUM [MART.]

Common Name

English

POTASSIUM TROCLOSENE [INCI]

Common Name

English

troclosene potassium [INN]

Common Name

English

1,3-DICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)TRIONE POTASSIUM SALT

Common Name

English

POTASSIUM TROCLOSENE

Official Name

English

TROCLOSENE POTASSIUM [USAN]

Common Name

English

NSC-251767

Code

English

TROCLOSENE POTASSIUM [MI]

Common Name

English

TROCLOSENE POTASSIUM [HSDB]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81403