BACITRACIN ZINC

US Approved OTC

First marketed in 1921

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Infection 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 8429	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date 1948
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 8429	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date 1957
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 8429	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date 1968

PubMed

Title	Date	PubMed
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.	1948 Mar	16561465
The Use of Bacitracin in Experimental Clostridium Welchii Infection in Guinea Pigs.	1949 Oct	17859460
Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.	1975 Jun 16	1175606
Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms.	1999 May	10215675
Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats.	1999 Oct	10498758
Copper transport and its defect in Wilson disease: characterization of the copper-binding domain of Wilson disease ATPase.	2000 Apr	10830865
Zinc and copper modulate differentially the P2X4 receptor.	2000 Apr	10737610
Chelation of zinc amplifies induction of growth hormone mRNA levels in cultured rat pituitary tumor cells.	2000 Feb	10720163
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.	2000 Feb 15	10673434
Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1.	2000 Mar 31	10734081
Cadmium mutagenicity and human nucleotide excision repair protein XPA: CD, EXAFS and (1)H/(15)N-NMR spectroscopic studies on the zinc(II)- and cadmium(II)-associated minimal DNA-binding domain (M98-F219).	2000 May	10783332
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.	2000 May 15	10797553
Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin.	2001	11842894
Dietary zinc deficiency increases uroguanylin accumulation in rat kidney.	2001 Apr	11260404
Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements.	2001 Jan 15	11163336
Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc.	2001 Mar	11181932
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001 Nov	11701772
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.	2002 Aug	12107072
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.	2002 Dec	12405537
Purification and characterization of cytosolic glycerol-3-phosphate dehydrogenase from skeletal muscle of jerboa (Jaculus orientalis).	2002 Feb	11952153
Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2.	2002 Jan	11781163
Allosteric modulation of beta2-adrenergic receptor by Zn(2+).	2002 Jan	11752207
Role of a copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin.	2002 Jan 15	11803044
Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.	2002 Jan 15	11803042
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.	2002 Jul 5	11983694
Partitioning of accumulated trace metals in the talitrid amphipod crustacean Orchestia gammarellus: a cautionary tale on the use of metallothionein-like proteins as biomarkers.	2002 Jun	11932003
White-sided dolphin metallothioneins: purification, characterisation and potential role.	2002 Mar	11912049
Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively.	2002 May 14	11994011
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.	2002 Nov	12429649
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.	2002 Nov	12421840
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).	2002 Oct 25	12192006
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.	2003 Apr	12714242
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.	2003 Apr	12679171
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.	2003 Aug 15	12915106
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.	2003 Aug 19	12911326
Activation of the rainbow trout metallothionein-A promoter by silver and zinc.	2003 Jan	12524046
Differential effects of zinc on functionally distinct human growth hormone mutations.	2003 Jul	12915731
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003 Jun	12798935
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003 May 2	12595529
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.	2003 Oct 3	12885774
Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants.	2004 Mar	12639846

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Substance Class	Mixture Created by `admin` on `Fri Dec 15 16:04:25 GMT 2023` Edited by `admin` on `Fri Dec 15 16:04:25 GMT 2023`
Record UNII	89Y4M234ES
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BACITRACIN ZINC

Common Name

English

NEO-POLYCIN COMPONENT BACITRACIN ZINC

Common Name

English

BACITRACIN ZINC [GREEN BOOK]

Common Name

English

BACITRACIN ZINC [MART.]

Common Name

English

BACITRACIN ZINC [VANDF]

Common Name

English

BACITRACIN ZINC [USP-RS]

Common Name

English

BACITRACIN ZINC COMPONENT OF OCUMYCIN

Common Name

English

BACITRACIN ZINC [EP MONOGRAPH]

Common Name

English

POLYSPORIN COMPONENT BACITRACIN ZINC

Common Name

English

Bacitracins zinc complex

Common Name

English

BACITRACIN ZINC COMPONENT OF NEO-POLYCIN

Common Name

English

BACITRACIN ZINC COMPONENT OF LANABIOTIC

Common Name

English

BACITRACIN ZINC [WHO-IP]

Common Name

English

BACITRACIN ZINC [USP MONOGRAPH]

Common Name

English

LANABIOTIC COMPONENT BACITRACIN ZINC

Common Name

English

BACITRACIN ZINC [MI]

Common Name

English

BACITRACIN ZINC [ORANGE BOOK]

Common Name

English

ZINC BACITRACIN

Common Name

English

NOPTRACIN

Common Name

English

BACITRACINUM ZINCUM [WHO-IP LATIN]

Common Name

English

BACIFARMIN

Common Name

English

BACITRACIN ZINC COMPONENT OF POLYSPORIN

Common Name

English

Bacitracin zinc [WHO-DD]

Common Name

English

BACITRACINS, ZINC COMPLEX

Common Name

English

ZIBA-RX

Brand Name

English

OCUMYCIN COMPONENT BACITRACIN ZINC

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 333.120