Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H23N2S.Cl |
Molecular Weight | 334.907 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].CC(CN1C2=CC=CC=C2SC3=C1C=CC=C3)[N+](C)(C)C
InChI
InChIKey=NGYRQLDJZVHTFE-UHFFFAOYSA-M
InChI=1S/C18H23N2S.ClH/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19;/h5-12,14H,13H2,1-4H3;1H/q+1;/p-1
Molecular Formula | C18H23N2S |
Molecular Weight | 299.454 |
Charge | 1 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Thiazinamium is an anti-cholinergic phenothiazine deriva¬tive, which also has antihistaminic properties. Intramuscular injection of Thiazinamium induces considerable bronchodilatation, but inconsistent results have been obtained after oral administration. The bioavailability of oral Thiazinamium is only 2-3% of that occurring after intramuscular injection. Intrarectal Thiazinamium is slightly better absorbed (3-9%). The elimination half-life of the parenteral drug is short, being about 20 minutes in most patients. Thiazinamium has been available for the treatment of asthma since the early 1960s but currently withdrawn in most countries. Compared with inhaled ipratropium bromide, intramuscular Thiazinamium and intramuscular atropine were associated with 'extremely frequent side-effects’. Notable tachycardia occurred shortly after intramuscular injection of Thiazinamium in two trials. Dry mouth was reported as ‘frequent’ with oral Thiazinamium, and micturition problems of moderate severity affected 13% of patients.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:15:32 GMT 2023
by
admin
on
Fri Dec 15 15:15:32 GMT 2023
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Record UNII |
89SV0QH69Q
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Record Status |
Validated (UNII)
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Record Version |
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-
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Official Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29578
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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Code System | Code | Type | Description | ||
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C81153
Created by
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PRIMARY | |||
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89SV0QH69Q
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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PRIMARY | |||
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DTXSID40962956
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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20316
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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CHEMBL2111135
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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PRIMARY | |||
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4320-13-2
Created by
admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |