NORGESTRIENONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H22O2
Molecular Weight	294.3875
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)C=CC3=C4CCC(=O)C=C4CC[C@@]23[H]

InChI

InChIKey=GVDMJXQHPUYPHP-FYQPLNBISA-N

InChI=1S/C20H22O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,8,10,12,17-18,22H,4-7,9,11H2,2H3/t17-,18+,19+,20+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H22O2
Molecular Weight	294.3875
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://medicament.ooreka.fr/medicament/voir/20349/ogyline
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/527342

Norgestrienone is a synthetic progwstin which was used as an oral contraceptive under the names Ogyline and Planor.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Progesterone receptor 61 Target ID: CHEMBL208 Sources: https://www.ncbi.nlm.nih.gov/pubmed/527342	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pregnancy 65 Sources: https://monographs.iarc.fr/ENG/Monographs/vol72/mono72-7.pdf	Preventing		Approved 8429	OGYLINE Approved Use Unknown

PubMed

Title	Date	PubMed
[Arterial hypertension during treatment with estro-progestative drugs].	1971 Sep-Oct	5153254
[Acquired angioneurotic edema induced by hormonal contraception].	2003 May 24	12870385
Hereditary angio-oedema: effective treatment with the progestogen-only pill in a young woman.	2004 Sep	15377369

Patents

Sample Use Guides

In Vivo Use Guide

One tablet (350 ug) per day without interruption, at a fixed time, so that the interval between taking 2 tablets is always 24 hours.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:53:33 GMT 2023` Edited by `admin` on `Sat Dec 16 15:53:33 GMT 2023`
Record UNII	89386PYU9O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORGESTRIENONE

Official Name

English

Norgestrienone [WHO-DD]

Common Name

English

NORGESTRIENONE [MART.]

Common Name

English

NSC-101105

Code

English

17-HYDROXY-19-NOR-17.ALPHA.-PREGNA-4,9,11-TRIEN-20-YN-3-ONE

Common Name

English

NORGESTRIENONE [MI]

Common Name

English

norgestrienone [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

G03AC07