SERMORELIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18031173 | https://www.ncbi.nlm.nih.gov/pubmed/18046908 | https://www.ncbi.nlm.nih.gov/pubmed/2429796

Sermorelin, a 29 amino acid analog of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with a full biological activity of GHRH which is used as a diagnostic agent to assess growth hormone (GH) secretion for the purpose of diagnosing growth hormone deficiency. Intravenous and subcutaneous sermorelin specifically stimulate growth hormone secretion from the anterior pituitary. Sermorelin binds to the growth hormone releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion. Hormone responses to intravenous sermorelin appear to be a rapid and relatively specific test for the diagnosis of growth hormone deficiency.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
growth hormone deficiency 2 Sources: https://www.drugs.com/cons/geref.html	Diagnostic		Approved 8583	GEREF Approved Use Diagnosing and treating growth hormone deficiency in children Launch Date 1990

Sample Use Guides

In Vivo Use Guide

1 mcg/kg bodyweight

Route of Administration: Intravenous

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:35:59 GMT 2025` Edited by `admin` on `Mon Mar 31 20:35:59 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	89243S03TE
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SERMORELIN

Official Name

English

GROLIBERIN

Preferred Name

English

sermorelin [INN]

Common Name

English

Sermorelin [WHO-DD]

Common Name

English

SERMORELIN [MI]

Common Name

English

SERMORELIN [VANDF]

Common Name

English

GROWTH HORMONE-RELEASING FACTOR (HUMAN)-(1-29)-PEPTIDE AMIDE RECOMBINANT

Common Name

English

TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-NH2

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH01AC04

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

WHO-ATC

H01AC04

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

NCI_THESAURUS

C76358

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

WHO-VATC

QV04CD03

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

WIKIPEDIA

Designer-drugs-Sermorelin

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

WHO-ATC

V04CD03

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

Code System Code Type Description

FDA UNII

89243S03TE

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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SMS_ID

100000092087

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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DRUG BANK

DB00010

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DRUG CENTRAL

2433

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CAS

86168-78-7

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EPA CompTox

DTXSID70903978

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CHEBI

9118

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NCI_THESAURUS

C62088

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RXCUI

56188

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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RxNorm

WIKIPEDIA

Sermorelin

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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IUPHAR

6998

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EVMPD

SUB10496MIG

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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PUBCHEM

16132413

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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INN

6036

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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MERCK INDEX

m9870

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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Merck Index

MESH

D017337

Created by admin on Mon Mar 31 20:35:59 GMT 2025 , Edited by admin on Mon Mar 31 20:35:59 GMT 2025

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Related Record Type Details


					89243S03TE

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_29]		ARGININE		ARGININAMIDE, L-	29626ZE0WY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:SEQUENCE(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL