Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H5Cl5 |
| Molecular Weight | 326.433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=CC(=C1Cl)C2=C(Cl)C(Cl)=C(Cl)C=C2
InChI
InChIKey=AUGNBQPSMWGAJE-UHFFFAOYSA-N
InChI=1S/C12H5Cl5/c13-8-3-1-2-6(10(8)15)7-4-5-9(14)12(17)11(7)16/h1-5H
| Molecular Formula | C12H5Cl5 |
| Molecular Weight | 326.433 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015-12 |
|
| Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor 1254 are mainly associated with the dioxin-like constituents. | 2015-08 |
|
| The combined effects of DEHP and PCBs on phospholipase in the livers of mice. | 2015-02 |
|
| Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring. | 2014-08-17 |
|
| Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2014-04-15 |
|
| A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. | 2014-04 |
|
| Estrogen receptors are involved in polychlorinated biphenyl-induced apoptosis on mouse spermatocyte GC-2 cell line. | 2014-04 |
|
| YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. | 2014-03 |
|
| Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study. | 2013-12 |
|
| A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis. | 2013-08 |
|
| Effects of oil pollution and persistent organic pollutants (POPs) on glycerophospholipids in liver and brain of male Atlantic cod (Gadus morhua). | 2013-02 |
|
| Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. | 2012-12 |
|
| Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. | 2012-10-09 |
|
| Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat. | 2012-10-09 |
|
| The toxic effects of Aroclor 1254 exposure on the osteoblastic cell line MC3T3-E1 and its molecular mechanism. | 2012-05-16 |
|
| Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems. | 2012-02 |
|
| Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus. | 2011-11-01 |
|
| Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function. | 2011-11 |
|
| Embryotoxicity of lead (II) acetate and aroclor 1254 using a new end point of the embryonic stem cell test. | 2011-10 |
|
| Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. | 2011-09-05 |
|
| Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines. | 2011-04 |
|
| Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. | 2010-10-01 |
|
| Regulation of cytochrome P450 expression in Drosophila: Genomic insights. | 2010-06-01 |
|
| Modulatory effects of lycopene and ellagic acid on reproductive dysfunction induced by polychlorinated biphenyl (Aroclor 1254) in male rats. | 2010-06 |
|
| Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. | 2010-05-15 |
|
| Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice. | 2009-12-10 |
|
| An exploratory study of diabetes in a First Nation community with respect to serum concentrations of p,p'-DDE and PCBs and fish consumption. | 2009-12 |
|
| Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes. | 2009-08-21 |
|
| Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. | 2009-08 |
|
| Influence of aroclor 1254 on benzo(a)pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line. | 2009-08 |
|
| Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. | 2009-03 |
|
| Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. | 2009-01-10 |
|
| Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. | 2009-01 |
|
| Transcriptomic responses of European flounder (Platichthys flesus) to model toxicants. | 2008-11-11 |
|
| Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008-08 |
|
| Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model. | 2008-04 |
|
| Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes. | 2008-02 |
|
| Piscine UDP-glucuronosyltransferase 1B. | 2007-10-15 |
|
| Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. | 2007 |
|
| Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254. | 1998-03 |
|
| Modulation of the hepatic expression of the estrogen-regulated mRNA stabilizing factor by estrogenic and antiestrogenic nonsteroidal xenobiotics. | 1997-05-15 |
|
| Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity. | 1996-07 |
|
| Oxidative stress in fish exposed to model xenobiotics. Oxidatively modified forms of Cu,Zn-superoxide dismutase as potential biomarkers. | 1995-12-22 |
|
| Promotion of N-nitrosodiethylamine-initiated hepatocellular tumors and hepatoblastomas by 2,3,7,8-tetrachlorodibenzo-p-dioxin or Aroclor 1254 in C57BL/6, DBA/2, and B6D2F1 mice. | 1995-11-01 |
|
| Dissimilar frequency of hepatoblastomas and hepatic cystadenomas and adenocarcinomas arising in hepatocellular neoplasms of D2B6F1 mice initiated with N-nitrosodiethylamine and subsequently given Aroclor-1254, dichlorodiphenyltrichloroethane, or phenobarbital. | 1994-07-01 |
|
| Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf. | 1993-04-06 |
|
| Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. | 1987-04-21 |
|
| Detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or aroclor. | 1986-09-01 |
|
| Prominent role of DT-diaphorase as a cellular mechanism reducing chromium(VI) and reverting its mutagenicity. | 1985-07 |
|
| Modification of hexachlorophene toxicity by dieldrin and aroclor 1254. | 1974-09 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:32:17 GMT 2025
by
admin
on
Mon Mar 31 22:32:17 GMT 2025
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| Record UNII |
88Z0CKE07W
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| Record Status |
Validated (UNII)
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| Record Version |
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