COSDOSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 20:20:00 GMT 2025` Edited by `admin` on `Tue Apr 01 20:20:00 GMT 2025`
Sequence Type	OLIGONUCLEOTIDE
Record UNII	88SN5KG5CH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

cosdosiran [INN]

Preferred Name

English

COSDOSIRAN

Official Name

English

QPI-1007 FREE ACID

Code

English

RNA, (A-GM-G-AM-G-UM-U-CM-C-A-CM-A-UM-U-CM-U-GM-G-CM), COMPLEX WITH RNA ((1'-DE(6-AMINO-9H-PURIN-9-YL))DA-(5'->5')-G-C-C-A-G-A-A-U-G-U-G-G-A-A-C-U-C-DC-U) (1:1)

Systematic Name

English

Code System Code Type Description

CAS

1834560-88-1

Created by admin on Tue Apr 01 20:20:00 GMT 2025 , Edited by admin on Tue Apr 01 20:20:00 GMT 2025

PRIMARY

INN

10514

Created by admin on Tue Apr 01 20:20:00 GMT 2025 , Edited by admin on Tue Apr 01 20:20:00 GMT 2025

PRIMARY

FDA UNII

88SN5KG5CH

Created by admin on Tue Apr 01 20:20:00 GMT 2025 , Edited by admin on Tue Apr 01 20:20:00 GMT 2025

PRIMARY

NCI_THESAURUS

C171807

Created by admin on Tue Apr 01 20:20:00 GMT 2025 , Edited by admin on Tue Apr 01 20:20:00 GMT 2025

PRIMARY

SMS_ID

300000025214

Created by admin on Tue Apr 01 20:20:00 GMT 2025 , Edited by admin on Tue Apr 01 20:20:00 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	2_2;2_4;2_6;2_8;2_11;2_13;2_15;2_17;2_19	9 / 38
D-Ribose (RNA)	1_1-1_17;1_19;2_1;2_3;2_5;2_7;2_9-2_10;2_12;2_14;2_16;2_18	28 / 38
Deoxyribose (DNA)	1_18	1 / 38

Linkage	Site Range	Site Count
Phosphate	1_2-1_19;2_2-2_19	36 / 36

Related Record Type Details


					88SN5KG5CH

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	1_1		COSDOSIRAN 5' MODIFICAION	S9HXY54ZN8

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL