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Details

Stereochemistry ACHIRAL
Molecular Formula F.K.FH
Molecular Weight 78.103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of POTASSIUM BIFLUORIDE

SMILES

F.[F-].[K+]

InChI

InChIKey=VBKNTGMWIPUCRF-UHFFFAOYSA-M
InChI=1S/2FH.K/h2*1H;/q;;+1/p-1

HIDE SMILES / InChI
Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula FH
Molecular Weight 20.0063
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

1.27915196E12
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Approved
8429
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

-3.65299204E11
PubMed

PubMed

TitleDatePubMed
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
1972
Delayed cystitis due to cyclophosphamide.
1979 Jan 4
A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k.
1993 Mar 30
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 Dec 20
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
1994 Dec 20
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997 Aug 15
Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.
1997 Feb
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
1997 Nov
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
1998 Mar 6
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Effect of beta-blockers on free radical-induced cardiac contractile dysfunction.
1999 Jul 27
Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.
2000 Oct
Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals.
2001 Dec 5
Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1.
2001 Oct 5
Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress.
2003 Dec 19
Interactions of growth inhibitory factor with hydroxyl and superoxide radicals.
2003 Sep
Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction.
2004 Jan
[Water permeability of the OMCD and IMCD cells' basolateral membrane under the conditions of dehydration and dDAVP action].
2004 Jul
Biochemistry. Water photolysis in biology.
2004 Mar 19
Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney.
2004 Oct
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
2005 Feb 18
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.
2005 Sep
Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.
2006 Feb
Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system.
2006 Feb 21
Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample.
2006 Jun
Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney.
2007 May
A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell.
2009 Feb
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
2010 Sep 6
Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes.
2011 Mar
Water permeability and characterization of aquaporin-11.
2011 May
Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.
2012 Apr
Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation.
2012 Feb 1
Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells.
2012 Jun
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
2012 Jun 1
A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.
2012 May
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
2013 Feb
Patents

Patents

03930837
22
03931170
10
03931193
12
03931205
82
03931226
16
03931231
17
03931247
15
03932424
12
03932446
10
03932452
10
03932471
13
03932472
94
03932521
29
03932629
11
03933865
12
03933905
18
03933911
10
03934070
10
03937702
41
03937705
11
03937719
10
03937729
10
03937764
10
03939157
10
03939202
15
03940396
10
03940419
12
03941796
50
03941799
14
03941884
10
03943145
12
03943170
10
03943180
12
03946000
40
03946045
11
03947406
32
03947408
15
03947580
12
03950331
20
03950382
10
03950420
10
03950425
13
03952012
15
03952017
13
03952050
12
03952067
11
03953434
43
03953525
11
03953596
12
03954476
17
03954774
11
03954801
15
03956118
10
03956321
10
03959289
11
03970704
12
04002647
12
04008269
12
04029867
10
04128728
11
04134924
10
04136188
10
04511731
10
04532240
10
04568497
11
04691042
10
04826533
11
04844879
10
05187175
10
05302718
13
05403930
11
05527805
11
05556855
13
05607951
10
05658926
10
06156430
10
06649600
13
06703082
10
07250518
10
07354941
35
07494728
11
07655666
10
08012988
10
08436001
13
08481733
14
08501238
10
08513268
10
08614206
10
08669361
12
08741915
12
20030186989
11
20080153836
11
20090120802
11
20090286768
10
20100144747
11
20110251176
10
20110294818
10
20120208817
10
20130079321
10
20130203732
10
20130217666
10
7820025
11

Sample Use Guides

In Vivo Use Guide
10% Potassium Hydroxide
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 03:46:33 UTC 2023
Edited
by admin
on Sat Dec 16 03:46:33 UTC 2023
Record UNII
880X05W53M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM BIFLUORIDE
MI  
Common Name English
POTASSIUM FLUORIDE (K(HF2))
Common Name English
POTASSIUM BIFLUORIDE [MI]
Common Name English
HYDROGEN POTASSIUM DIFLUORIDE
Common Name English
POTASSIUM FLUORIDE HYDROFLUORIDE
Systematic Name English
POTASSIUM ACID BIFLUORIDE
Common Name English
POTASSIUM HYDROGEN FLUORIDE (KHF2)
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 75203
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
Code System Code Type Description
WIKIPEDIA
POTASSIUM BIFLUORIDE
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
ECHA (EC/EINECS)
232-156-2
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
FDA UNII
880X05W53M
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
PUBCHEM
11829350
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
CAS
7789-29-9
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
EPA CompTox
DTXSID10894159
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY
MERCK INDEX
m9001
Created by admin on Sat Dec 16 03:46:33 UTC 2023 , Edited by admin on Sat Dec 16 03:46:33 UTC 2023
PRIMARY Merck Index
NIH
NCATS
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