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Details

Stereochemistry ACHIRAL
Molecular Formula C8H20NO4P
Molecular Weight 225.2225
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CGP-35348

SMILES

CCOC(OCC)P(O)(=O)CCCN

InChI

InChIKey=QIIVUOWTHWIXFO-UHFFFAOYSA-N
InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)

HIDE SMILES / InChI

Molecular Formula C8H20NO4P
Molecular Weight 225.2225
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
27.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse.
1993 Apr
Antagonism of baclofen-induced depression of whole-cell synaptic currents in spinal dorsal horn neurones by the potent GABAB antagonist CGP55845.
1993 Dec
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
1995 Aug 18
CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat.
1996 Aug 23
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
1997 Mar 20
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
2002 Jul
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.
2002 Jun
The GABAB receptor and recognition memory: possible modulation of its behavioral effects by the nitrergic system.
2003
Hindquarters vasoconstriction through central GABA(B) receptors in conscious rats.
2003 Jul
Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors.
2004 Mar
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:56:26 GMT 2023
Edited
by admin
on Fri Dec 15 17:56:26 GMT 2023
Record UNII
87TI61875H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CGP-35348
Common Name English
3-AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID
Systematic Name English
Code System Code Type Description
CAS
123690-79-9
Created by admin on Fri Dec 15 17:56:26 GMT 2023 , Edited by admin on Fri Dec 15 17:56:26 GMT 2023
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EPA CompTox
DTXSID70154064
Created by admin on Fri Dec 15 17:56:26 GMT 2023 , Edited by admin on Fri Dec 15 17:56:26 GMT 2023
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FDA UNII
87TI61875H
Created by admin on Fri Dec 15 17:56:26 GMT 2023 , Edited by admin on Fri Dec 15 17:56:26 GMT 2023
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PUBCHEM
107699
Created by admin on Fri Dec 15 17:56:26 GMT 2023 , Edited by admin on Fri Dec 15 17:56:26 GMT 2023
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WIKIPEDIA
CGP-35348
Created by admin on Fri Dec 15 17:56:26 GMT 2023 , Edited by admin on Fri Dec 15 17:56:26 GMT 2023
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