INLEZIFIGENE CIVAPARVOVEC

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 15:34:51 GMT 2023` Edited by `admin` on `Sat Dec 16 15:34:51 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family	Parvoviridae
Organism Genus	Dependoparvovirus
Organism Species	adeno-associated dependoparvovirus a
Infraspecific Type	SUBSTRAIN
Infraspecific Name	rAAV(Rep2-Cap6)-ApoE / hAAT-ZFP 47171-FokI-ELD vector
Part	WHOLE
Record UNII	87RN2MR2FP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INLEZIFIGENE CIVAPARVOVEC

Official Name

English

inlezifigene civaparvovec [INN]

Common Name

English

A RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRUS TYPE 2/6 (RAAV REP2-CAP6) VECTOR, EXPRESSING A CDNA THAT TARGETS 447-461 BP OF THE ALBUMIN LOCUS (RELATIVE TO THE TRANSCRIPTION INITIATION SITE), FUSED TO THE OBLIGATE HETERODIMERIC FOKI NUCLEASE DOMAI

Systematic Name

English

Code System Code Type Description

FDA UNII

87RN2MR2FP

Created by admin on Sat Dec 16 15:34:51 GMT 2023 , Edited by admin on Sat Dec 16 15:34:51 GMT 2023

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CAS

2143578-31-6

Created by admin on Sat Dec 16 15:34:51 GMT 2023 , Edited by admin on Sat Dec 16 15:34:51 GMT 2023

PRIMARY

INN

10977

Created by admin on Sat Dec 16 15:34:51 GMT 2023 , Edited by admin on Sat Dec 16 15:34:51 GMT 2023

PRIMARY

NCI_THESAURUS

C175089

Created by admin on Sat Dec 16 15:34:51 GMT 2023 , Edited by admin on Sat Dec 16 15:34:51 GMT 2023

PRIMARY

Related Record Type Details


					87RN2MR2FP

INLEZIFIGENE CIVAPARVOVEC

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					INLEZIFIGENE CIVAPARVOVEC TRANSGENE INSERT	ZR4A4C333T