AROFYLLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H13ClN4O2
Molecular Weight	304.732
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCN1C(=O)N(C2=C(NC=N2)C1=O)C3=CC=C(Cl)C=C3

InChI

InChIKey=GVTLDPJNRVMCAL-UHFFFAOYSA-N

InChI=1S/C14H13ClN4O2/c1-2-7-18-13(20)11-12(17-8-16-11)19(14(18)21)10-5-3-9(15)4-6-10/h3-6,8H,2,7H2,1H3,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C14H13ClN4O2
Molecular Weight	304.732
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18046869 | https://www.ncbi.nlm.nih.gov/pubmed/16634702

Arofylline, a phosphodiesterase 4 inhibitor, participated in clinical trials phase III to treat patients with chronic obstructive pulmonary disease. Besides, in Spain, this drug participated in clinical trials for patients with asthma.

Originator

Approval Year

PubMed

Title	Date	PubMed
Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis.	2003 Jun	12791047
Biological targets for therapeutic interventions in COPD: clinical potential.	2006	18046869

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:20:13 GMT 2023` Edited by `admin` on `Sat Dec 16 16:20:13 GMT 2023`
Record UNII	87L38AY71R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AROFYLLINE

Official Name

English

LAS 31025

Code

English

AROFYLLINE [USAN]

Common Name

English

3-(P-CHLOROPHENYL)-1-PROPYLXANTHINE

Common Name

English

arofylline [INN]

Common Name

English

LAS-31025

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C744