PHENOXYISOPROPANOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H12O2
Molecular Weight	152.1904
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)COC1=CC=CC=C1

InChI

InChIKey=IBLKWZIFZMJLFL-UHFFFAOYSA-N

InChI=1S/C9H12O2/c1-8(10)7-11-9-5-3-2-4-6-9/h2-6,8,10H,7H2,1H3

HIDE SMILES / InChI

Molecular Formula	C9H12O2
Molecular Weight	152.1904
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=E778F744CF4A86ADCA2577DD00024581&agid=(PrintDetailsPublic)&actionid=1
Curator's Comment: Description was created based on several sources, including http://www.viacheminc.com/wp-content/uploads/Tech-Data-Sheet-Protectol-PP.pdf

Phenoxyisopropanol is used as an approved preservative. Protectol PP preservative is a mixture of 1- Phenoxy-2-propanol (phenoxyisopropanol) and 2-Phenoxy-1-propanol, is widely accepted around the world and is allowed as a preservative in cosmetics, toiletries and household products. Phenoxyisopropanol is a component of Clearasil daily face wash, used to prevent pimples, keep pores clear where pimples start, deep clean, remove dirt and oil.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Propionibacterium acnes growth 1 Target ID: Propionibacterium acnes growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/6231455	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acne 98 Sources: http://www.ncbi.nlm.nih.gov/pubmed/146628	Preventing		Approved 8429	CLEARASIL Approved Use May help prevent pimples; keeps pores clear where pimples start; deep cleans; removes dirt and oil. Launch Date 1997

PubMed

Title	Date	PubMed
Activation of pig liver esterase in organic media with organic polymers: application to the enantioselective acylation of racemic functionalized secondary alcohols.	2001 May 18	11348121
Oral absorption, metabolism and excretion of 1-phenoxy-2-propanol in rats.	2003 Oct	14555341
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists.	2006 Apr 15	16386423
1-Phenoxy-2-propanol is a useful anaesthetic for gastropods used in neurophysiology.	2009 Jan 30	18809433
Development and Validation of a RPLC Method for the Determination of 2-Phenoxyethanol in Senselle Lubricant Formulation.	2010 May	21188039

Patents

Sample Use Guides

In Vivo Use Guide

topical lotion

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:15:04 GMT 2023` Edited by `admin` on `Fri Dec 15 17:15:04 GMT 2023`
Record UNII	87CZY0NY1A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENOXYISOPROPANOL

Official Name

English

PHENOXYISOPROPANOL [MART.]

Common Name

English

Propylene phenoxetol

Common Name

English

(±)-1-Phenoxy-2-propanol

Systematic Name

English

NSC-24015

Code

English

1-PHENOXY-2-PROPANOL

Systematic Name

English

DOWANOL PPH GLYCOL ETHER

Brand Name

English

PHENOXYISOPROPANOL [INCI]

Common Name

English

PROPYLENE GLYCOL PHENYL ETHER

Systematic Name

English

Phenoxyisopropanol [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000078901